Medicinal composition of liposoluble vitamin injection (I) and water-soluble vitamin for injection and preparation method thereof

A technology of fat-soluble vitamins and water-soluble vitamins, applied in the field of medicine, can solve problems such as vitamin stability, vitamin curative effect reduction, and human health damage, so as to improve clinical application quality and bioavailability, and improve safety Sexuality and cost-saving effect

Active Publication Date: 2012-06-27
HAINAN MEILAN SMITH KLINE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

③ Most of the vitamins cannot be synthesized by the body or the amount of synthesis is insufficient to meet the needs of the body and must be obtained from food frequently
④The human body has a very small requirement for vitamins, and the daily requirement is often calculated in milligrams (mg) or micrograms (μg), but once it is deficient, it will cause corresponding vitamin deficiency and cause damage to human health
The above-mentioned mixed preparations do not actually solve the technical problem of vitamin stability well, and also lead to the reduction of the curative effect of vitamins.

Method used

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  • Medicinal composition of liposoluble vitamin injection (I) and water-soluble vitamin for injection and preparation method thereof
  • Medicinal composition of liposoluble vitamin injection (I) and water-soluble vitamin for injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1 Preparation of Combination Packaged Drugs

[0044] 1, the preparation of fat-soluble vitamin injection (I)

[0045] (1) Weigh vitamin A 0.69g, vitamin E 6.4g, vitamin D 2 10mg, Vitamin K 1 0.2g, 1000g of soybean oil for injection, 120g of lecithin for injection, 220g of glycerin, fully stir and mix until the main drug is completely dissolved, then add 9000ml of water for injection, stir well, add water for injection to 10000ml, and stir;

[0046] (2) Adjust the pH value to 8.0 with 1mol / L sodium hydroxide solution, add 3g of activated carbon to stir and adsorb, and filter for decarburization;

[0047] (3) Fine filtration, filling, 10ml / bottle;

[0048] (4) Sterilize by autoclaving at 121° C. for 15 minutes.

[0049] 2. Preparation of water-soluble vitamins for injection

[0050] (1) Weigh vitamin B respectively 1 3.1g, vitamin B 2 4.9g, Niacinamide 40g, Vitamin B 6 4.9g, sodium pantothenate 16.5g, vitamin C sodium 113g, biotin 60mg, folic acid 0.4g, ...

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Abstract

The invention relates to a medicinal composition of a liposoluble vitamin injection (I) and a water-soluble vitamin for injection, in particular to a combined application package. The medicinal composition contains the liposoluble vitamin injection (I) and the water-soluble vitamin for injection. When in use, the medicinal composition is dissolved or diluted by using water for injection or glucose injection firstly, and then is subjected to intravenous drip respectively. In the combined application package, vitamins required by a human body are comprehensively implemented, the defect caused by using a single vitamin is overcome, and the treatment effect is greatly improved.

Description

technical field [0001] The invention relates to a pharmaceutical composition of vitamins for injection, in particular to a composition of fat-soluble vitamin injection (I) and water-soluble vitamins for injection, a preparation method and application packaging, and belongs to the technical field of medicine. Background technique [0002] Vitamins are a type of trace organic substances necessary for humans and animals to maintain normal physiological functions. They play an important role in the process of human growth, metabolism, and development. When humans and animals lack vitamins, they cannot grow normally and develop specific lesions. , the so-called vitamin deficiency. [0003] Vitamins are also known as vitamins. Generally speaking, they are life-sustaining substances. They are a type of organic substances necessary to maintain human life activities, and are also important active substances to maintain human health. Vitamins are present in small amounts in the body,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/714A61K31/592A61K31/355A61K31/122A61K31/07A61K31/51A61K31/525A61K31/455A61K31/4415A61K31/197A61K31/375A61K31/4188A61K31/519A61K9/08A61K9/19A61P3/02
Inventor 杨明贵公长春
Owner HAINAN MEILAN SMITH KLINE PHARMA
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