Oil-in-water type compound ylang ylang oil nano-emulsion oral solution and preparation method thereof

An oral emulsion and oil-in-water technology, which is applied in the field of medicine, can solve the problems of many adverse reactions, unsuitable long-term use, and high irritation, and achieves the effects of clear and transparent appearance, improved sensory quality, and low production cost.

Inactive Publication Date: 2012-07-18
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the medicines for the treatment of hypertension are mainly western medicines, but they are highly irritating and have many adverse reactions, so they are not suitable for long-term use

Method used

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  • Oil-in-water type compound ylang ylang oil nano-emulsion oral solution and preparation method thereof
  • Oil-in-water type compound ylang ylang oil nano-emulsion oral solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] 1) Weigh 28.9g of RH-40, 2.3g of absolute ethanol, 5.2g of ylang-ylang oil, purple

[0046] Perilla seed oil 3.7g, linseed oil 3.6g, distilled water 56.3g, spare;

[0047] 2) Stir the stated amount of ylang-ylang oil, perilla seed oil and linseed oil evenly as the oil phase;

[0048] 3) Add the amount of surfactant and co-surfactant into the oil phase and mix well;

[0049] 4) Use distilled water as the water phase, stir the oil phase quickly at room temperature, and slowly add dropwise while stirring

[0050] The water phase is continuously stirred until the system becomes a transparent liquid, and the oil-in-water compound Ylang-ylang oil nanoemulsion oral liquid is obtained.

Embodiment 2

[0052] Tween-80 29.5g, absolute ethanol 1.4g, ylang-ylang oil 4.8g, perilla seed oil 3.0g, flax

[0053] It consists of 3.2g of seed oil and 58.1g of distilled water.

Embodiment 3

[0055]EL-40 27.4g, absolute ethanol 3.1g, ylang ylang oil 7.4g, perilla seed oil 3.9g, linseed

[0056] Composition of oil 4.3g, distilled water 53.9g.

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Abstract

The invention discloses an oil-in-water type compound ylang ylang oil nano-emulsion oral solution which consists of the following raw materials in percentage by mass: 25.0 to 35.0 percent of surfactant, 0 to 5.0 percent of cosurfactant, 1.3 to 9.0 percent of ylang ylang oil, 1.0 to 6.0 percent of purple perilla seed oil, 0.9 to 5.8 percent of flaxseed oil and the balance of distilled water. The compound ylang ylang oil nano-emulsion oral solution has the functions of reducing hypertension and blood fat and preventing cardiovascular and cerebrovascular diseases, has high stability, high content of effective components, high oral bioavailability, lasting action time, remarkable effect and convenient popularization and application, and has greatly application prospect in the medicine market.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a compound ylang-ylang oil nanoemulsion oral liquid for lowering blood pressure, lowering blood fat and preventing cardiovascular and cerebrovascular diseases and a preparation method thereof. [0002] Background technique [0003] In the past 40 years, the proportion of cardiovascular and cerebrovascular diseases in my country's residents' deaths has increased from 10.07% to 39.4%. At present, the total number of cerebrovascular patients exceeds 100 million, and the number of patients is increasing at a rate of 3 million every year. Among them, the main factor is high blood pressure. Elevated blood pressure is the fuse of many diseases, which will increase the risk of coronary heart disease, heart failure, kidney disease and other diseases. Because some hypertensive patients have no obvious clinical symptoms, hypertension is also known as the "invisible killer" of human health. Therefore...

Claims

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Application Information

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IPC IPC(8): A61K36/55A61K9/107A61P3/06A61P9/10A61P9/12
Inventor 欧阳五庆郑星星孙江宏
Owner NORTHWEST A & F UNIV
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