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Oil-in-water cinnamomum camphora oil nano-emulsion preparation and preparation method thereof

A technology of oil-in-water type and linoleum oil, which is applied in the field of medicine, can solve the problems of easy volatilization and poor stability, and achieve the effects of promoting absorption, improving dispersion and uniform particle size

Inactive Publication Date: 2020-12-01
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention enhances its transdermal absorption capacity by making linoleum oil into nanoemulsion, and also solves the problems of linoleum oil being volatile and poor in stability during actual production, transportation and storage

Method used

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  • Oil-in-water cinnamomum camphora oil nano-emulsion preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Mix 2.00g of absolute ethanol with 0.10g of linalool oil and 0.10g of wheat germ oil to fully dissolve the linalool oil; add 20.00g of RH-40, stir well to obtain a clear solution; then slowly add 77.80g of distilled water and stir , until a clear, transparent, low viscosity and fluidity colorless or yellow solution is formed.

Embodiment 2

[0058] Lin camphor oil 5.00g, liquid paraffin 1.00g, EL-40 25.00g, 1,2-propanediol 5.00g, distilled water 64.00g

[0059] The specific operation steps are the same as those in Example 1.

Embodiment 3

[0061] Lin camphor oil 10.00g, IPM 5.00g, Tween-80 30.00g, glycerin 10.00g, distilled water 45.00g

[0062] The specific operation steps are the same as those in Example 1.

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Abstract

The invention discloses an oil-in-water cinnamomum camphora oil nano-emulsion preparation. The preparation is composed of the following components in percentage by mass: 0.10%-20.00% of cinnamomum camphora oil, 20.00%-45.00% of a surfactant, 2.00%-20.00% of a co-surfactant, 0-20.00% of an oil phase, and the balance distilled water, wherein the sum of the mass percentages of the components is 100%.The cinnamomum camphora oil nano-emulsion preparation is colorless or yellow transparent in appearance, has a particle size of 1-100 nm, is good in stability, is high in safety, is low in viscosity,is simple in preparation method, is stable in storage, and is good in transdermal property. The cinnamomum camphora oil nano-emulsion preparation can be directly smeared on the skin surface clinically, and is extremely convenient to use.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new formulation of linalool oil, in particular to an oil-in-water linalool oil nanoemulsion preparation and a preparation method thereof. Background technique [0002] Lin camphor oil is a colorless or light yellow to reddish-brown oily liquid, soluble in ethanol and ether, with strong camphor odor, high ash content, and strong volatility. Linalam oil is anti-inflammatory, analgesic, anti-depressant, antibacterial, insecticidal, laxative, warms the skin, energizes, induces perspiration, repels insects, treats wounds, repels mosquitoes and insects, sterilizes and relieves itching, removes foot odor, prevents beriberi , purify the air, etc. Lin camphor oil is often used for anti-inflammatory, analgesic, anti-mosquito and insect repellent in practical applications. Most of the camphor products currently used are chemical synthetic products, and the dosage forms are mostly limited to solid p...

Claims

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Application Information

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IPC IPC(8): A61K36/54A61K9/107A61K47/44A61K47/10A61K47/26A61P29/00A61P17/02
CPCA61K9/0014A61K9/1075A61K36/54A61K47/10A61K47/26A61K47/44A61P17/02A61P29/00
Inventor 欧阳五庆郑寅魏云鹏
Owner NORTHWEST A & F UNIV
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