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Sodium sulfadiazine compound preparation for treating pig brain hydropsy, and preparation method and application thereof

A technology of sulfadiazine sodium and compound preparations, which is applied in the preparation of drugs for porcine cerebral edema disease. In the field of sulfadiazine sodium compound preparations, it can solve the problems of searching for sulfadiazine sodium compound preparations, and achieve scientific and reasonable prescriptions and simple preparation processes. , low cost effect

Inactive Publication Date: 2012-07-18
河南省针剂兽药工程技术研究中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, no relevant reports on the application of sulfadiazine sodium compound preparations in the preparation of drugs for the treatment of porcine brain edema have been retrieved in the open literature

Method used

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  • Sodium sulfadiazine compound preparation for treating pig brain hydropsy, and preparation method and application thereof
  • Sodium sulfadiazine compound preparation for treating pig brain hydropsy, and preparation method and application thereof
  • Sodium sulfadiazine compound preparation for treating pig brain hydropsy, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1, sulfadiazine sodium compound preparation and preparation method thereof

[0019] prescription:

[0020]

[0021] Process: Dissolve 100g of sulfadiazine sodium and 50g of mannitol in 200mL of water; dissolve 10g of furosemide and 20g of trimethoprim in 50mL of glycerin formal, mix the two solutions and stir evenly; adjust the pH value to 10.0~10.5, mix well, add water for injection to the full amount, filter, fill, crimp and seal.

Embodiment 2

[0022] Embodiment 2, sulfadiazine sodium compound preparation and preparation method thereof

[0023] prescription:

[0024]

[0025] Process: Take 400mL of water to dissolve 200g of sulfadiazine sodium and 150g of mannitol; take 100mL of glycerin formal to dissolve 30g of furosemide and 40g of trimethoprim, mix the two solutions and stir evenly; add sodium hydroxide solution to adjust the pH value to 10.0~10.5, mix well, add water for injection to the full amount, filter, fill, crimp and seal.

Embodiment 3

[0026] Embodiment 3, sulfadiazine sodium compound preparation and preparation method thereof

[0027] prescription:

[0028]

[0029]

[0030] Process: Take 600mL of water to dissolve 300g of sulfadiazine sodium and 250g of mannitol; take 150mL of glycerin formal to dissolve 50g of furosemide and 20g of trimethoprim, mix the two solutions and stir evenly; add sodium hydroxide solution to adjust the pH value to 10.0~10.5, mix well, add water for injection to the full amount, filter, fill, crimp and seal.

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PUM

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Abstract

The invention discloses a sodium sulfadiazine compound preparation for treating pig brain hydropsy, and a preparation method and application thereof, and belongs to the technical field of veterinary medicines. The sodium sulfadiazine compound preparation comprises sodium sulfadiazine, mannitol, furosemide, trimethoprim and the like. The sodium sulfadiazine compound preparation is scientific and reasonable in formula, safe in auxiliary material, controllable in quality, high in stability and low in cost, and a preparation process is simple and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, relates to a compound preparation of sulfadiazine sodium, and particularly relates to the application of the compound preparation in the preparation of porcine cerebral edema medicine. Background technique [0002] Cerebral edema is relatively common in human clinical practice. The principle of treatment is not only the cause, but also symptomatic treatment. The principle is to reduce swelling, reduce brain volume or surgical decompression. Modern medicine mainly uses oral diuretics and hormonal drugs, such as mannitol, glycerol fructose, scopolamine, nimodipine, dexamethasone, etc., but these drugs can only temporarily relieve symptoms and have certain side effects on the human body. There are objections to their clinical use. Patent Publication No. CN101590210 reports a Chinese medicine composition for treating cerebral edema without any adverse reaction after use, but the preparati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/635A61P7/10A61P31/04A61K31/047A61K31/505A61K31/506
Inventor 饶刚李逐波廖丹丹徐高贤徐泽民
Owner 河南省针剂兽药工程技术研究中心
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