Unlock instant, AI-driven research and patent intelligence for your innovation.

Application of curcumin C and derivative C3 thereof in preparing medicine for preventing macular degeneration of retina

A technology of curcumin derivatives and macular degeneration, applied in the fields of biology and medicine, can solve problems such as unrealizable, shallow research foundation, etc., and achieve the effects of no toxic side effects and high curative effect

Active Publication Date: 2014-04-23
XI AN JIAOTONG UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The proposal, establishment and development of tissue engineering provide a new strategy for tissue and organ defect repair and functional reconstruction. It can repair larger tissue or organ defects with a small amount of seed cells expanded in vitro and combined with biomaterials. Reconstruction of physiological functions provides guidance for the ultimate realization of non-invasive repair of tissue defects and true reconstruction of shape, structure and function, but its research foundation is too shallow to be realized

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of curcumin C and derivative C3 thereof in preparing medicine for preventing macular degeneration of retina
  • Application of curcumin C and derivative C3 thereof in preparing medicine for preventing macular degeneration of retina
  • Application of curcumin C and derivative C3 thereof in preparing medicine for preventing macular degeneration of retina

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0025] 1. Cell culture

[0026] ARPE cells are cultured in DF / 12 medium containing 10% (v / v) fetal bovine serum, grown adherently, 5% CO2, and cultured in an incubator at 37°C. According to different experimental requirements, they can be cultured at 10 cm. Plate, 6-well plate and 96-well plate.

[0027] 2. Damage and protection model

[0028] Use acrolein 75μmol / L damage and curcumin 1μmol / L, 5μmol / L and C30.5μmol / L protection models

[0029] 3. Related results

[0030] (1) Curcumin (C) and its derivatives (C3) have inhibitory effects on acrolein-induced ARPE cell death.

[0031] MTT colorimetry is often used to detect cell viability or growth status. The succinate dehydrogenase in the mitochondria of living cells can reduce exogenous MTT into water-insoluble blue-purple crystal formazan (Formazan) and deposit it in the cells, while dead cells have no such ability. Dimethyl sulfoxide (DMSO) can dissolve formazan in cells. The light absorption value is measured at 590nm wavelength wit...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an application of curcumin C and a derivative C3 thereof in preparing medicine for preventing macular degeneration of retina. The curcumin C and the derivative C3 thereof have an effect on inhibiting acute retinal pegment epitheliitis (ARPE) cell death induced by acrolein, have an action on inhibiting deterioration of ARPE cell mitochondrial membrane induced by the acrolein and have a function on inhibiting the production of active oxygen radicals induced by the acrolein; and the protective mechanism of the curcumin C and the derivative C3 thereof is completed by activating a phase-II enzyme protective system of the cell. The curcumin C and the derivative C3 thereof have pharmacological actions such as anti-oxidation, anti-inflammation, tumor resistance, choleretic effect, toxicity resistance of liver cells, antirheumatic, bacteriostasis, hypotension resistance, low cholesterol resistance and senile dementia resistance, and belong to the safe and simplified medicine with high curative effect.

Description

Technical field [0001] The present invention relates to the fields of biology and medicine, in particular to the application of curcumin C and its derivative C3 in drugs for preventing and treating macular degeneration of the retina. Background technique [0002] Age-related macular degeneration (AMD) is one of the blinding eye diseases that occur in middle-aged and elderly people. Its etiology is unknown. It may be related to long-term chronic light damage of the macula, heredity, metabolism, ethnicity, diet and other factors. Research results show that the onset of AMD is closely related to the atrophy and degeneration of retinal pigment epithelium (RPE) cells. RPE cells are located between the neural retina and the choroid. Under normal circumstances, RPE cells play a key role in many important ocular functions, such as phagocytosis of the outer segment of photoreceptor cells, physiological adsorption of neural retina, blood retina The maintenance and the transportation and s...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/12A61P27/02
Inventor 刘健康冯智辉邹璇曹可岳婷婷周波
Owner XI AN JIAOTONG UNIV
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com