Traditional Chinese medical composition for prevention and treatment of A type clostridiosis welchii, extract, preparation and preparation method and application

Clostridium welchii disease and composition technology, applied in the field of traditional Chinese medicine composition, can solve problems such as poisoning and death of infected animals, destruction of normal intestinal flora, poor feeding and management, etc., to increase conversion rate, increase spleen index and thymus Exponential, increased bioavailability effect

Active Publication Date: 2013-09-11
重庆西农大科信动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In fact, Clostridium welchii type A is an opportunistic pathogenic bacterium, which will not cause disease under normal circumstances, but when the sanitary conditions are poor, the feeding management is poor, the feed is suddenly changed, improperly matched, and the crude fiber is insufficient, the environment in the intestinal tract Changes occur, and the normal flora of the intestinal tract is destroyed, causing Clostridium welchii type A to multiply and produce exotoxin of Clostridium welchii type A, which causes poisoning and death of infected animals

Method used

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  • Traditional Chinese medical composition for prevention and treatment of A type clostridiosis welchii, extract, preparation and preparation method and application
  • Traditional Chinese medical composition for prevention and treatment of A type clostridiosis welchii, extract, preparation and preparation method and application
  • Traditional Chinese medical composition for prevention and treatment of A type clostridiosis welchii, extract, preparation and preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The traditional Chinese medicine composition of prevention and treatment of rabbit type A clostridioides welchii disease, by weight, consists of the components described in table 1:

[0033] Table 1 prevents and treats the formula of the traditional Chinese medicine composition of rabbit type A clostridium welchiisis

[0034] formula

Embodiment 2

[0036] The extract of the traditional Chinese medicine composition is prepared, and the specific steps are:

[0037] (1) Take each medicinal material by portion, mix, pulverize, add water equivalent to 10 times the weight of the medicinal material, and soak for 1 hour;

[0038] (2) Decoct the medicinal material obtained in step (1) twice, the first time for 2 hours, the second time for 1.5 hours, then filter with gauze, and collect the filtrate to obtain the decoction;

[0039] (3) Add ethanol with a volume fraction equal to that of the decoction liquid to 95% of the decoction liquid obtained in step (2), place it in a refrigerator at 4°C overnight, then filter it with filter paper, collect the filtrate, and use the filtrate Rotary evaporator was pumped and concentrated until the crude drug concentration was 1g / ml (crude drug concentration refers to the mass ratio of the medicinal material to the volume of the concentrated solution) to obtain the Chinese medicine composition e...

Embodiment 3

[0042] The extract of the Chinese medicine composition prepared in Example 2 is used to prepare the granules of the Chinese medicine composition for preventing and treating rabbit type A clostridioides welchii disease:

[0043] In parts by weight, it is made from the components described in Table 2:

[0044] The composition of the granule of table 2 Chinese medicine composition

[0045] formula

Recipe 1

Recipe 2

Recipe 3

Extract (parts)

47

88

134

Solid dispersant (parts)

polyethylene glycol 400

Cellulose 800

Surfactant 1000

Adhesive (parts)

Starch 1200

Starch 1600

Cellulose 1800

Filler (parts)

Calcium hydrogen phosphate 300

Sucrose 500

Lactose 600

Humectant (parts)

Ethanol 140

Ethanol 180

Distilled water 200

Fragrance (parts)

Herbal Essence 40

Orange Peel Oil 60

Cinnamon Oil 75

[0046] The preparation method of traditional Chinese medic...

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PUM

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Abstract

The invention discloses a traditional Chinese medical composition for prevention and treatment of A type clostridiosis welchii, which consists of the following components by weight: 10-80 parts of mahonia fortunei, 5-50 parts of pulsatilla chinensis, 3-50 parts of yam, 3-30 parts of semen plantaginis, 3-30 parts of sanguisorba officinalis, 3-30 parts of rheum officinale and 5-45 parts of acalypha australis. The invention also discloses an extract prepared with the composition, a preparation method of the extract, a preparation prepared with the extract and application of the preparation. The composition, the extract and the preparation have broad values in medical application for prevention and treatment of the A type clostridiosis welchii.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for preventing and treating Clostridium welchiisis type A in rabbits, an extract and a preparation method of the traditional Chinese medicine composition, and a preparation prepared from the extract and its application. Background technique [0002] Clostridium welchii disease type A, also known as Clostridium perfringens, is a common acute fatal diarrheal disease with high morbidity and mortality, which is extremely harmful to the aquaculture industry. Once infected, it is easy to cause Huge economic loss. Traditional Chinese medicine believes that this disease is internal heat caused by external evils entering the interior. In fact, Clostridium welchii type A is an opportunistic pathogenic bacterium, which will not cause disease under normal circumstances, but when the sanitary conditions are poor, the feeding management i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8945A61P31/04
Inventor 刘娟朱兆荣郭志兴凌榕槟
Owner 重庆西农大科信动物药业有限公司
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