Traditional Chinese medicinal composition pulvis and tablets for treating primary osteoporosis, preparation method thereof and health-care product

An osteoporosis and composition technology, applied in the field of traditional Chinese medicine, can solve the problems of adverse reactions, less active ingredients, limited absorption, etc., and achieve the effects of low price, less side effects, and improving joint function

Inactive Publication Date: 2012-08-01
TAISHAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, in the clinical treatment of primary osteoporosis, the main drugs used in western medicine are: (1) Drugs that inhibit bone resorption (such as: estrogen, calcitonin, bisphosphonates, isoflavones, etc.) ; (2) Bone-promoting drugs (such as fluoride, parathyroid hormone, etc.); (3) Bone mineralization drugs (such as calcium, vitamin D and its derivatives), but the above-mentioned drugs or Too little active ingredient, limited absorption, or significant adverse effects, making it not an ideal drug for the treatment of primary osteoporosis

Method used

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  • Traditional Chinese medicinal composition pulvis and tablets for treating primary osteoporosis, preparation method thereof and health-care product

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Effect test

preparation example Construction

[0050] When the dosage form of the Chinese medicine composition of the present invention is decoction, its preparation method comprises the following steps:

[0051] A, the components are mixed in proportion and pulverized into powder;

[0052] B. Add the powder obtained in step A into cold water and soak for 15 hours to 21 hours, decoct with a slow fire for 1 hour to 3 hours, filter the decoction to obtain the first filtrate, the quality of the added water is 3 to 6 times the mass of the powder obtained in step A;

[0053] C. Add the filter residue obtained by filtering in step B into cold water again, decoct with slow fire for 1 hour to 3 hours, and filter to obtain the second filtrate. The quality of the added water is the same as that in step B;

[0054] D. Combine the two filtrates, concentrate under reduced pressure to remove part of the water, and obtain the decoction. The crude drug amount of the decoction is preferably 1.5 g / ml-3 g / ml.

[0055] When the traditional ...

Embodiment 1

[0073] Embodiment 1 Acute toxicity test and long-term toxicity test of Chinese medicine composition of the present invention

[0074] 1. Acute toxicity test

[0075] According to the relevant regulations on the research of new drugs of traditional Chinese medicine, the decoction was administered to mice, and the median lethal dose (LD) 50 ) was experimentally determined, but LD was not detected 50, so a maximum tolerated dose test was performed. Results: with the maximum concentration (60%), the maximum dosage (120ml / kg, given four times in one day) 100g / Kg orally, equivalent to 60g / kg of crude drug, equivalent to 100% of adult clinical proposed daily dose 300 times (according to 75kg), none of the mice died within seven days, and no toxic reaction was found in the organs of the sacrificed mice, and there was no difference between the administration group and the control group mice.

[0076] 2. Long-term toxicity test

[0077] For the safety of clinical medication, accordi...

Embodiment 2

[0079] Embodiment 2 The decoction prepared by the Chinese medicine composition of the present invention

[0080] Mix 18g safflower, 30g cistanche, 12g cnidium, 25g deerbite, 45g drynaria, 22g Caulis Spatholobus, 16g Dendrobium, 21g black sesame, 14g Eupatorium, 20g yam, 13g Poria cocos, 25g Codonopsis pilosula, and grind them into Powder; soak the obtained powder in 1000g of cold water for 20 hours, decoct with a slow fire for 3 hours, filter the decoction to obtain the first filtrate; add the filtered residue into 1000g of cold water again, and decoct with a slow fire Boil for 3 hours, filter to obtain the second filtrate, the quality of the added water is the same as in step B; combine the two filtrates, concentrate under reduced pressure to remove part of the water, and obtain the decoction, the crude drug amount of the decoction is 2g / ml.

[0081]

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Abstract

The invention provides a traditional Chinese medicinal composition pulvis for treating primary osteoporosis. The traditional Chinese medicinal composition comprises the following components: safflower, cistanche deserticola, fructus cnidii, pyrola, drynaria rhizome, suberect spatholobus stem, dendrobe, black sesame, herba lycopi, Chinese yam, tuckahoe and codonopsis pilosula. The traditional Chinese medicinal composition can provide positive interference and treatment on primary osteoporosis, relieve the bone ache of a patient, improve the function of joints, improve the action ability in daily life and reduce the risk of bone fracture, and is low in side effect and low in price at the same time.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating primary osteoporosis. [0002] Background technique [0003] Osteoporosis (osteoporosis, OP) refers to the absolute reduction of the total amount of bone tissue per unit volume (the ratio of mineralization and bone matrix in the bone is normal), which changes the structure and function of the bone, resulting in increased bone fragility, resulting in Systemic skeletal diseases characterized by low back pain in limbs, pathological fractures, and body deformation are characterized by osteopenia and degenerative changes in bone tissue structure, resulting in increased bone fragility and susceptibility to fractures. The morbidity rate of my country's elderly women is as high as 90.5%, and that of elderly men reaches 60.7%. It is predicted that in the middle of the 21st century, the total number of elderly ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8984A61P19/10
Inventor 胡海波刘海春王霞王磊
Owner TAISHAN MEDICAL UNIV
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