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Oral sustained-release Anemone flaccida Fr. Schmidt saponin W3 capsule and preparation method thereof

A technology of slow-release capsules and diguanin, which is applied in medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of frequent medications and large dosages, and achieve low cost , easy to control, low investment effect

Inactive Publication Date: 2012-08-08
广州康和药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen from this that the daily dosage of oral solid preparation prepared by Diwu extract has reached 1.2g, which is a large dosage and more times of medication in a single day.

Method used

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  • Oral sustained-release Anemone flaccida Fr. Schmidt saponin W3 capsule and preparation method thereof
  • Oral sustained-release Anemone flaccida Fr. Schmidt saponin W3 capsule and preparation method thereof
  • Oral sustained-release Anemone flaccida Fr. Schmidt saponin W3 capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031]

[0032]

[0033] (1) Povidone and diguanin W 3 Add to 95% ethanol, stir and dissolve into a transparent and clear solution;

[0034] (2) Use an atomizing spray gun to spray the above solution onto a blank ball core with a diameter of 75-150 μm, and dry it to obtain diguanin W 3 Contains medicated pellets.

[0035] (3) Dissolve Eudragit RS100 and EC with an appropriate amount of solvent to dissolve the slow-release material, and at the same time, add triethyl citrate, talcum powder, and magnesium stearate into an appropriate amount of solvent to form a suspension, and then Add this suspension to the above-mentioned slow-release material solution and mix evenly under the condition of stirring to make a slow-release coating liquid;

[0036] (4) Spray the coating solution prepared in step (3) onto the diguanin W prepared in step (2) using an atomizing spray gun 3 On the drug-containing pellets, the coating solution should be continuously stirred during the coating...

Embodiment 2

[0039]

[0040] (1) Povidone and diguanin W 3 Add to 95% ethanol, stir and dissolve into a transparent and clear solution;

[0041] (2) Use an atomizing spray gun to spray the above solution onto a blank ball core with a diameter of 150-300 μm, and dry it to obtain diguanin W 3 Contains medicated pellets.

[0042](3) Dissolve Eudragit RL100, Eudragit RS30D, and EC with an appropriate amount of solvent to dissolve the slow-release material, and at the same time, add triethyl citrate, talcum powder, and magnesium stearate into an appropriate amount of solvent to form a suspension , and then add this suspension to the above-mentioned slow-release material solution under stirring and mix evenly to make a slow-release coating solution;

[0043] (4) Spray the coating solution prepared in step (3) onto the diguanin W prepared in step (2) using an atomizing spray gun 3 On the drug-containing pellets, the coating solution should be continuously stirred during the coating process,...

Embodiment 3

[0046]

[0047] (1) Povidone and diguanin W 3 Add to 95% ethanol, stir and dissolve into a transparent and clear solution;

[0048] (2) Use an atomizing spray gun to spray the above solution onto a blank pellet core with a diameter of 100-200 μm, and dry it to obtain diguanin W 3 Contains medicated pellets.

[0049] (3) Dissolve Eudragit RD100, Eudragit RL100, and EC with an appropriate amount of solvent to dissolve the slow-release material, and at the same time, add triethyl citrate, talcum powder, and magnesium stearate into an appropriate amount of solvent to form a suspension , and then add this suspension to the above-mentioned slow-release material solution under stirring and mix evenly to make a slow-release coating solution;

[0050] (4) Spray the coating solution prepared in step (3) onto the diguanin W prepared in step (2) using an atomizing spray gun 3 On the drug-containing pellets, the coating solution should be continuously stirred during the coating proce...

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Abstract

The invention discloses an oral sustained-release Anemone flaccida Fr. Schmidt saponin W3 capsule and a preparation method thereof. The oral sustained-release Anemone flaccida Fr. Schmidt saponin W3 capsule comprises Anemone flaccida Fr. Schmidt saponin W3, polyvinylpyrrolidone, Eudragit and other common auxiliary materials. The preparation method comprises the following steps of preparing a drug-containing coating liquid, carrying out coating to form a drug-containing sustained-release film, preparing a sustained-release coating liquid arranged outside a drug layer, carrying out coating to form a sustained-release film outside the drug layer, preparing sustained-release pills and carrying out capsule loading. After oral administration, the oral sustained-release Anemone flaccida Fr. Schmidt saponin W3 capsule can realize lasting and stable plasma concentration.

Description

technical field [0001] The present invention relates to a kind of kusaponin W 3 The oral sustained-release capsule and a preparation method thereof are medicines for treating rheumatoid arthritis and belong to the field of pharmaceutical preparations. Background technique [0002] Diwu, the scientific name is Anemone flaccida Fr.Schmidt, also known as mine, black mine, gold beads, centipede notoginseng, Scherichia chinensis, etc.; it belongs to Ranunculaceae Anemone (Ranunculaceae Anemone.), a perennial herb with dried rhizomes Can be used as medicine later. It is recorded in "Chinese Materia Medica", "National Chinese Herbal Medicine Compilation", "Guizhou Folk Medicine", "Zhejiang Tianmu Yam Zhizhi", etc. hit damage. [0003] Hubei College of Traditional Chinese Medicine, Bing Feihong and others obtained the extract from Centipede Sanqi to make Diwufengshian Capsules for the treatment of rheumatoid arthritis; Guangzhou Kanghe Pharmaceutical Co., Ltd. obtained the title ...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K31/704A61K47/14A61K47/26A61K47/32A61K47/34A61K47/36A61K47/38A61P19/02A61P29/00
Inventor 于江月裴红黄福华龚明鹏吴振斌黄珍玉
Owner 广州康和药业有限公司
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