Composition for preventing or improving hyperlipidemia and supplementing vitamin D

A technology for hyperlipidemia and composition, which is applied in the field of composition for preventing or improving hyperlipidemia, and can solve problems such as limited effects and no involvement of fish oil and vitamin D in intervening hyperlipidemia

Active Publication Date: 2012-08-15
SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its effect is limited, and it is necessary to improve its curative effect by various means
[0005] However, the current study did not address the role of fish oil and vitamin D in the intervention of hyperlipidemia

Method used

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  • Composition for preventing or improving hyperlipidemia and supplementing vitamin D
  • Composition for preventing or improving hyperlipidemia and supplementing vitamin D
  • Composition for preventing or improving hyperlipidemia and supplementing vitamin D

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0125] Embodiment 1, the effect of fish oil vitamin D joint ((a) formula) on rat food intake and body weight

[0126] During the experiment, the rats had smooth coats and were in good condition; their food intake was relatively stable, and there was no significant difference between the food intake of the experimental group rats, the hyperlipidemia model control group, and the normal control group (P>0.05). See figure 1 . The weight gain of animals in each experimental group was relatively stable, no obvious abnormal features were found, and no natural death occurred.

[0127] Many research data show that obesity is closely related to health. Obesity is not only a chronic disease that endangers health, but also one of the risk factors for various chronic non-communicable diseases such as diabetes, hypertension, hyperlipidemia, and fatty liver.

[0128] The risk of hypertension, hyperlipidemia, hyperglycemia and fatty liver is greatly increased in overweight and obese persons...

Embodiment 2

[0130] Embodiment 2, the effect of fish oil vitamin D joint ((a) formula) on rat blood lipid level

[0131] 1. Effect of fish oil vitamin D combination ((a) formula) on cholesterol level in rats

[0132] Cholesterol is involved in the formation of cell membranes and is a raw material for the synthesis of bile acids, vitamin D and steroid hormones. A high concentration of cholesterol in the blood will lead to increased blood viscosity, slowed blood flow, insufficient cardiovascular and cerebrovascular blood supply, and a series of cardiovascular and cerebrovascular diseases such as cerebral thrombosis, coronary heart disease, and cerebral apoplexy, which can lead to death in severe cases. Therefore, cholesterol level is one of the important indicators to measure whether blood lipids are normal or not [Li Changgui, Wang Jun, Dong Yanhu. Control goals and modern understanding of diabetic dyslipidemia [J]. Liaoning Journal of Practical Diabetes. 2001, 1: 4-16].

[0133] There are...

Embodiment 3

[0152] The effect test of the fish oil-vitamin D mixture of embodiment 3, (b)-(d) formula

[0153] According to the same animal test method described in Example 2, the only difference is that the formula (b)-(d) in Table 3 was used to replace the formula (a) in Example 2 in the fish oil VD group to test the blood lipid-lowering effect of the mixture. The results are shown in Table 5-Table 7.

[0154] table 5

[0155]

cholesterol

Triglycerides

HDL-C*

LDL-C

olive oil control group

0.32

2.26

-0.42

2.62

fish oil group

30.62

65.67

-24.6

49.77

VD group

0.93

24.89

-18.57

-2.28

Fish oil VD group ((b) formula)

33.50

62.96

-58.58

56.6

[0156] * Among them, "-" indicates that the indicator has increased.

[0157] Table 6

[0158]

cholesterol

Triglycerides

HDL-C*

LDL-C

olive oil control group

0...

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PUM

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Abstract

The invention relates to a composition for preventing or improving hyperlipidemia and supplementing vitamin D. According to the invention, fish oil and vitamin D are combined firstly for medicinal purpose; and unexpectedly, the combination of the two is found to have the capability of effectively reducing contents of cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C) in mammal blood, and effectively improve the content of high density lipoprotein (HDL-C) in mammal blood. Therefore, the combination is applicable to the improvement of hyperlipidemia and hypercholesterolemia.

Description

technical field [0001] The invention belongs to the field of pharmacy and health products; more specifically, the invention relates to a composition for preventing or improving hyperlipidemia. Background technique [0002] Hyperlipidemia is a disease characterized by an abnormal increase in one or more lipid components in plasma. The atherosclerosis caused by this disease is an important risk factor for the development of cardiovascular diseases such as coronary heart disease and hypertension, which seriously threatens Human health [Yusuf S, Reddy S, S, Anand S. Global burden of cardiovascular diseases, part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation 2001; 104: 2746-2753]. About 12 million people die of cardiovascular disease every year in the world [Wang Haiyong, Wang Lin. Research progress of blood lipid-lowering drugs [J]. Foreign Medical Pharmacy Volume, 2004, (3): 160-166]. In the past 20 years, the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/60A23L1/29A61P3/06A61K31/59A23L33/00
Inventor 王福俤郭艳红周玉付
Owner SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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