Composition for amelioration of body lipid

A composition and a technology for abnormal lipid metabolism, applied in the field of a novel composition for improving abnormal lipid metabolism in the body, can solve problems such as allergic problems, not widely used, and high cost, and achieve improved sensitivity and improved lipid metabolism Abnormal, prevent arteriosclerosis effect

Inactive Publication Date: 2008-09-03
CHIKUNO SHOKUHIN INDS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, although these compositions etc. have the effect of reducing cholesterol and neutral fat, the action is slow, and there are allergic problems, etc., so they are not widely used.
In addition, if fractional purification is carried out in order to improve the action, the possibility of removing allergies is high, but the cost becomes high, so it is economically inferior

Method used

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  • Composition for amelioration of body lipid
  • Composition for amelioration of body lipid
  • Composition for amelioration of body lipid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] 30 L of water was added to 3 kg of defatted rice bran, and the mixture was stirred at room temperature for 1 hour while adjusting the pH to 8.5 with a 25 W / V% aqueous sodium hydroxide solution. Thereafter, it was separated into an extract and a residue by centrifugation (1500 rpm×30 seconds). 60% by volume of sulfuric acid was added to the separated extract to adjust the pH to 3.0, followed by stirring at room temperature for 1 hour. Then, the precipitate was separated by centrifugation (3000 rpm×1 minute). The acid precipitated (isolated) protein was recovered and dried by freeze drying. The yield of the dried product was 230 g, and the yield was 7.7%. The protein content determined by the Kjeldahl method is 65%, and the rice bran extract containing high-concentration rice bran protein is obtained.

Embodiment 2

[0066] A rice bran extract containing a high concentration of rice bran protein was obtained in the same manner as in Example 1, except that 36% by volume of hydrochloric acid was added instead of 60% by volume of sulfuric acid. The yield of the rice bran extract containing rice bran protein was 241 g, and the yield was 8.0%. The protein content was determined to be 63% by the Kjeldahl method.

Embodiment 3

[0068] 10 g of the rice bran extract containing rice bran protein obtained in Example 1 was suspended in 60 mL of 60% by volume aqueous ethanol, and stirred for 5 minutes. After stirring, the precipitate was recovered by centrifugation (3000 rpm×10 minutes). This precipitate was further suspended in 300 mL of 99.5% ethanol, stirred for 5 minutes, recovered by centrifugation (3000 rpm x 10 minutes), and dried by freeze-drying. The yield of the obtained rice bran extract containing purified rice bran protein was 8.2 g, and the yield was 82% (6.3% in terms of defatted rice bran). The protein content determined by the Kjeldahl method was 75.0%.

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Abstract

The present invention prepares a composition by extracting a rice bran extract containing a rice bran protein and separating the protein from the extract, wherein the composition has an excellent amelioration effect on abnormal lipid metabolism, shows a prophylactic or ameliorating effect on hyperlipemia, obesity or type II diabetes induced by abnormal lipid metabolism, is economically advantageous, and is safe with respect to allergy. A composition for use in the amelioration of abnormal lipid metabolism comprising a rice bran protein.

Description

technical field [0001] The present invention relates to a composition for improving abnormal lipid metabolism containing rice bran protein. More specifically, the present invention relates to a novel composition for improving abnormal lipid metabolism in vivo, which contains rice bran protein obtained from rice bran and reduces lipids such as cholesterol and neutral fat in blood and liver. Background technique [0002] In addition to lipids, proteins, and dietary fibers, rice bran is a valuable plant resource rich in vitamins and minerals. About 900,000 tons of rice bran are produced in Japan every year, and rice bran oil produced from rice bran is a valuable domestic vegetable oil in Japan. [0003] The residue obtained by extracting rice bran oil from rice bran is defatted rice bran, and the defatted rice bran contains components other than lipids among the active ingredients listed above. Various attempts have been made so far regarding the use of the defatted rice bran...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A23L1/305A61K38/00A61P3/04A61P3/06A61P3/10
CPCA23V2002/00A61K36/899A61K38/168A23L33/185A61P3/10A61P3/12A61P3/04A61P3/06A23V2200/328A23V2200/332A23V2250/5482A61K38/00
Inventor 筑野卓夫狩谷哲也垣内信南由美小山淳志石本贵子
Owner CHIKUNO SHOKUHIN INDS
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