Application of Vorinostat in preparation of soft-resistant Eimeria drugs

A technology of Eimeria, vorinostat, applied in the field of vorinostat

Active Publication Date: 2012-08-22
INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] So far, there is no report that vorinostat has anti-Eimeria tenella, and it is impossib

Method used

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  • Application of Vorinostat in preparation of soft-resistant Eimeria drugs
  • Application of Vorinostat in preparation of soft-resistant Eimeria drugs
  • Application of Vorinostat in preparation of soft-resistant Eimeria drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Preparation of vorinostat powder: take 5g of vorinostat (content not less than 99%) and 95g of starch and mix well.

[0012] The usage and dosage of the powder: mix the above 100g powder into 100 kg of feed, and feed according to the daily food intake.

Embodiment 2

[0014] Preparation of vorinostat water-soluble powder: Mix 2.5 g of vorinostat (with a content of not less than 99%) and 97.5 g of glucose.

[0015] Usage and dosage of water-soluble powder: dissolve the above-mentioned 100g powder in 100 liters of water. Cut off the water for 2 hours before the treatment, and then feed according to the normal drinking water amount.

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Abstract

The invention discloses application of Vorinostat in preparation of soft-resistant Eimeria drugs; powder is formed by the Vorinostat and an acceptable auxiliary material, and then is added into a feed to mix uniformly so as to feed chicken by a daily feed amount; or a Vorinostat water-soluble powder is prepared by the Vorinostat, and is dissolved in water to feed chicken by a daily feed amount. Animal infection experiments confirm an anticoccidia index (ACI) of the Vorinostat is more than 175, and the Vorinostat has function of resisting soft-resistant Eimeria.

Description

technical field [0001] The invention relates to a new application of vorinostat, in particular to the application of vorinostat in the preparation of anti-Eimeria tenella medicaments. Background technique [0002] Chicken coccidiosis is the most important disease that seriously endangers the intensive chicken industry production, and the economic loss caused by it is as high as more than 2.5 billion pounds every year. Eimeriaspp ), the most harmful of which is Eimeria tenella ( Eimeria tenella ). Although my country has no accurate statistics on this so far, the most conservative estimate is that the loss should not be less than 2.5 billion RMB. Chemical drug treatment is one of the important measures to control coccidiosis in chickens, but at present chicken coccidiosis has extensive and serious drug resistance, and new anticoccidiosis drugs are urgently needed to be put on the market. [0003] Vorinostat (chemical name: N-hydroxy-N'-phenylsuberamide, Vorinostat), the m...

Claims

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Application Information

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IPC IPC(8): A61K31/167A61P33/02
Inventor 孙铭飞谢明权戚南山吴彩艳吕敏娜廖申权温烈娜
Owner INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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