Photo-sensitizer composition, and using method and application thereof

Abstract

The invention discloses a photo-sensitizer composition, and a using method and application thereof. The photo-sensitizer composition contains an active ingredient consisting of 5-aminolevulinic acid (5-ALA) or derivative thereof and hydroxypropyl methyl cellulose (HPMC), wherein, the mass ratio of the active ingredient to HPMC is 2:1-5:1. The composition is simple in formula, and a gelatinous swelling body can be quickly formed by mixing the composition and water in a certain ratio. Because the 5-ALA does not react with HPMC, incompatibility is not produced; and two main components can be stored in the same container, so that the production, packing and storage costs are reduced. The invention also discloses application of the composition in preparation of medicaments for diagnosing or treating mucosal part diseases.

Description

technical field

[0001] The present invention belongs to the field of pharmacy; more specifically, the present invention relates to a composition containing 5-aminolevulinic acid or its derivatives and its application method, and also relates to the preparation of the composition for diagnosing or treating mucosal diseases. Drug use. Background technique

[0002] Photodynamic therapy (PDT) is a relatively new technique that has been used to treat various diseases. The currently marketed active ingredients for photodynamic therapy and diagnosis are mainly 5-aminolevulinic acid (5-ALA) or its esters.

[0003] It has been reported in the literature that 5-ALA or its derivatives can be used to treat various malignant or non-malignant skin, conjunctiva, respiratory tract and vaginal mucosa, endometrium, cervical cancer, etc. Bladder epithelial lesions and neoplastic diseases. For example, the methyl ester of 5-ALA developed by Photocure ASA (Oslo, Norway) and the hexyl ester ...

Examples

preparation example Construction

[0056] The photosensitizer composition of the present invention can be conveniently prepared after knowing the raw materials used and their formulations. The preparation method includes: mixing the photosensitizer composition with water to form a swelling product, and the mass ratio of the active ingredient to water in the swelling product is 1:9-1:3. The swollen product can be directly administered to the mucous membrane site of the patient as an administration preparation.

[0057] The present invention also provides a kit, which contains a kit for diagnosing or treating mucosal diseases, including: the photosensitizer composition described in the present invention; Use the instruction manual of the kit, which can record the method and ratio of photosensitizer composition and water compatibility.

Embodiment 8

[0107] Embodiment 8, medicine box

[0108] A kit is prepared, comprising:

[0109] The first container: wherein 4 parts by weight of 5-ALA are housed as an active ingredient;

[0110] The second container: the HPMC K100 of 1 weight part is housed therein; 0.336 weight part povidone (PVP) K30; 0.0128 weight part ethylparaben; 0.064 weight part polyethylene glycol; 0.002 weight part edetate di sodium.

[0111] When in use, first dissolve the content in the second container in water, then add the active ingredient in the first container, and apply it on the affected part after it dissolves.

technical field

[0001] The present invention belongs to the field of pharmacy; more specifically, the present invention relates to a composition containing 5-aminolevulinic acid or its derivatives and its application method, and also relates to the preparation of the composition for diagnosing or treating mucosal diseases. Drug use. Background technique

[0002] Photodynamic therapy (PDT) is a relatively new technique that has been used to treat various diseases. The currently marketed active ingredients for photodynamic therapy and diagnosis are mainly 5-aminolevulinic acid (5-ALA) or its esters.

[0003] It has been reported in the literature that 5-ALA or its derivatives can be used to treat various malignant or non-malignant skin, conjunctiva, respiratory tract and vaginal mucosa, endometrium, cervical cancer, etc. Bladder epithelial lesions and neoplastic diseases. For example, the methyl ester of 5-ALA developed by Photocure ASA (Oslo, Norway) and the hexyl ester ...

Examples

preparation example Construction

[0056] The photosensitizer composition of the present invention can be conveniently prepared after knowing the raw materials used and their formulations. The preparation method includes: mixing the photosensitizer composition with water to form a swelling product, and the mass ratio of the active ingredient to water in the swelling product is 1:9-1:3. The swollen product can be directly administered to the mucous membrane site of the patient as an administration preparation.

[0057] The present invention also provides a kit, which contains a kit for diagnosing or treating mucosal diseases, including: the photosensitizer composition described in the present invention; Use the instruction manual of the kit, which can record the method and ratio of photosensitizer composition and water compatibility.

Embodiment 8

[0107] Embodiment 8, medicine box

[0108] A kit is prepared, comprising:

[0109] The first container: wherein 4 parts by weight of 5-ALA are housed as an active ingredient;

[0110] The second container: the HPMC K100 of 1 weight part is housed therein; 0.336 weight part povidone (PVP) K30; 0.0128 weight part ethylparaben; 0.064 weight part polyethylene glycol; 0.002 weight part edetate di sodium.

[0111] When in use, first dissolve the content in the second container in water, then add the active ingredient in the first container, and apply it on the affected part after it dissolves.

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