The invention belongs to the field of insecticides, specifically to an anthranilamide compound insect disinfestation preparation and a use method thereof, wherein the active component in the insect disinfestation preparation is the compound having the structure represented by the following figure, the active component, at least a carrier and at least a surfactant are mixed to prepare emulsifiable concentrate, aqueous emulsion, microemulsion, soluble liquid agent, dispersible oil agent, ultra-low volume agent, powder, wettable powder, suspension, dispersible oil suspension, seed treatment agent, granules, water dispersible granules, emulsifiable powder, emulsifiable granules, effervescent granules, effervescent tablets, microcapsule granules, microcapsule suspension, sustained-release granules, ointments, aerosol or smoke agent, and in any case, the selection of the type of the preparation depends on the physical, chemical and biological properties of the active component. According to the present invention, with the preparation type, Chilo suppressalis, Ostrinia nubilalis, Mythimna separata, Plutella xylostella, Spodoptera exigua Hiibner larva and other pests can be efficiently prevented and controlled.