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Traditional Chinese medicine combination for treating ulcerative colitis and preparation method thereof

A technology of ulcerative colitis and composition, which is applied in the field of medicine, can solve the problems of poor curative effect and difficulty in achieving satisfactory results in the treatment of UC, and achieve the effect of convenient administration

Inactive Publication Date: 2012-09-19
高娟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many traditional Chinese medicine formulas for the treatment of ulcerative colitis. After repeated clinical trials, we found that their curative effect is not good, and it is difficult to achieve satisfactory results in the treatment of UC.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Chinese medicine composition formula for treating ulcerative colitis: Pulsatilla 15g, Radix Astragali 15g, Stir-fried Atractylodes Rhizoma 15g, Bletilla striata 15g, Dijincao 25g, Psoraleae 15g, Agrimony 15g, Galla chinensis 15g, Sophora japonica rice 10g, Bupleurum 20g, Danshen 15g.

[0019] Preparation method: firstly take Pulsatilla grandis, fried Atractylodes macrocephala, Bletilla striata, Dijincao, psoraleae, Agrimony, Galla chinensis, dry and pulverize to 120 mesh fine powder; add astragalus, Sophora japonica rice, Bupleurum chinensis, and Salvia miltiorrhiza to half prescription amount, add water and boil for two The second time, combine two water decoctions, concentrate to extract concentrated solution with a specific gravity of 1.2-1.8, and set aside; spray the extract on fine powder to make soft materials, sieve to make wet granules, dry at 55-65°C, and then prepare The active ingredient of a drug; the active ingredient is formulated into granules.

[0020] ...

Embodiment 2

[0022] The formula of traditional Chinese medicine composition for treating ulcerative colitis: Pulsatilla 20g, Radix Astragali 10g, Stir-fried Atractylodes Rhizoma 20g, Bletilla striata 10g, Dijincao 30g, Psoraleae 10g, Agrimony 20g, Galla chinensis 10g, Sophora japonica rice 15g, Bupleurum 15g, Danshen 10g.

[0023] The preparation method and consumption are the same as in Example 1.

Embodiment 3

[0025] Traditional Chinese medicine composition formula for treating ulcerative colitis: Pulsatilla 10g, Radix Astragali 20g, Stir-fried Atractylodes Rhizoma 10g, Bletilla striata 20g, Dijincao 20g, Psoraleae 20g, Agrimony 10g, Chinese gallnut 20g, Sophora japonica rice 5g, Bupleurum 25g, Danshen 20g.

[0026] The preparation method and consumption are the same as in Example 1.

[0027] For showing the therapeutic effect of Chinese medicine composition of the present invention to ulcerative colitis, the present invention verifies as follows:

[0028] General data: 61 routine UC cases, all select case from outpatient service and hospitalized patient, be divided into 2 groups at random, treatment group (select the granule prepared in embodiment 1) altogether 32 examples, 16 examples are male, 16 examples are female, age (35.9 ±15.3) years old, disease duration (4.8±2.0) years. The control group (using western medicine sulfasalazine) included 29 cases, 13 males and 16 females, ...

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Abstract

The invention discloses a traditional Chinese medicine combination for treating ulcerative colitis and a preparation method thereof. The traditional Chinese medicine combination is prepared from the following raw medicines in parts by weight: 10-20 grams of Chinese pulsatilla root, 10-20 grams of astragalus, 10-20 grams of parched atractylodes rhizome, 10-20 grams of bletilla striata, 20-30 grams of humifuse euphorbia herb, 10-20 grams of fructus psoraleae, 10-20 grams of hairyvein agrimony, 10-20 grams of gallnut, 5-10 grams of sophora flower bud, 15-25 grams of bupleurum root and 10-20 grams of red sage root. The preparation method comprises the following steps of: firstly taking the Chinese pulsatilla root, the parched atractylodes rhizome, the bletilla striata, the humifuse euphorbia herb, the fructus psoraleae, the hairyvein agrimony and the gallnut, drying and smashing into 120-mesh fine powder; taking half prescribed doses of the astragalus, the sophora flower bud, the bupleurum root and the red sage root, adding water, decocting twice, mixing two types of water decoctions, concentrating till obtaining an extracting concentrated solution with a specific gravity of 1.2-1.8 for later use; and spraying the extracting solution on the fine powder to obtain a soft material, sieving to obtain wet particles, drying at a temperature of 55-65 DEG C to obtain active constituents of the medicine. The traditional Chinese medicine combination disclosed by the invention has the beneficial effects of meeting requirements of clinical medication of Chinese medicines, maintaining the characteristics of syndrome differentiation and treatment of the Chinese medicine and being taken conveniently.

Description

[0001] technical field [0002] The invention belongs to the technical field of medicine, and in particular relates to a traditional Chinese medicine composition for treating ulcerative colitis and a preparation method thereof. Background technique [0003] Ulcerative colitis (UC) is a chronic non-specific inflammatory disease with unknown etiology, mainly occurring in the mucosa and submucosa of the large intestine. The pathogenesis of ulcerative colitis (UC) can be summarized as that environmental factors act on genetically susceptible individuals, and with the participation of intestinal flora, the intestinal immune and non-immune systems are activated, leading to immune responses and inflammatory processes, and ultimately cause tissue inflammation. damage. The pathogenesis of traditional Chinese medicine is mainly due to dysfunction of viscera, disorder of qi movement, accumulation of dampness and heat, damage to intestines and collaterals, and over time, spleen and kid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61P1/04
Inventor 高娟
Owner 高娟
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