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Double-cavity bagged vitamin C injection and preparation method thereof

A technology for vitamins and injections, applied in the field of medicine, can solve the problems affecting the effectiveness and safety of clinical use, the decrease of vitamin C content, and the increase of related substances, etc., and achieve the convenience of clinical use, stable preparations, content and related substances. Effect

Inactive Publication Date: 2012-10-03
SICHUAN KELUN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This phenomenon shows that vitamin C exists in the injection and reacts to reduce the content of vitamin C and increase the related substances, thus affecting the effectiveness and safety of clinical use.

Method used

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  • Double-cavity bagged vitamin C injection and preparation method thereof
  • Double-cavity bagged vitamin C injection and preparation method thereof
  • Double-cavity bagged vitamin C injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Vitamin C 1g

[0059] Glucose 5g

[0060] Vitamin C comes in powder form.

[0061] Preparation of glucose solution: Weigh 5g of glucose, dissolve it with water for injection to make a 100ml solution, add activated carbon to boil, filter, and the pH value is stable at 3.8-4.5.

[0062] Fill the above vitamin C powder and glucose solution into two adjacent chambers of the double-chamber bag respectively, separated by a weak seal to obtain the vitamin C / glucose aqueous solution packaged in the double-chamber bag. In clinical use, gently squeeze the chamber filled with the solution, the weak seal will open, and the two chambers will communicate with each other and mix evenly to obtain clinically used vitamin C / glucose injection. At this time, the concentration of vitamin C is 1% (W / V), the glucose concentration is 5% (W / V).

Embodiment 2

[0064] Vitamin C 1g

[0065] Glucose 12.5g

[0066] Vitamin C comes in powder form.

[0067] Preparation of glucose solution: Weigh 12.5g of glucose, dissolve it with water for injection to make a 250ml solution, add activated carbon to boil, filter, and the pH value is stable at 3.8-4.5.

[0068] Fill the above vitamin C powder and glucose solution into two adjacent chambers of the double-chamber bag respectively, separated by a weak seal to obtain the vitamin C / glucose aqueous solution packaged in the double-chamber bag. In clinical use, gently squeeze the chamber filled with the solution, the weak seal will open, and the two chambers will communicate with each other and mix evenly to obtain clinically used vitamin C / glucose injection. At this time, the concentration of vitamin C is 0.4% (W / V), the glucose concentration is 5% (W / V).

Embodiment 3

[0070] Vitamin C 2.5g

[0071] Glucose 5g

[0072] Vitamin C comes in powder form.

[0073] Preparation of glucose solution: Weigh 5g of glucose, dissolve it with water for injection to make a 100ml solution, add activated carbon to boil, filter, and the pH value is stable at 3.8-4.5.

[0074] Fill the above vitamin C powder and glucose solution into two adjacent chambers of the double-chamber bag respectively, separated by a weak seal to obtain the vitamin C / glucose aqueous solution packaged in the double-chamber bag. In clinical use, gently squeeze the chamber filled with the solution, the weak seal will open, and the two chambers will communicate with each other and mix evenly to obtain clinically used vitamin C / glucose injection. At this time, the concentration of vitamin C is 2.5% (W / V), the glucose concentration is 5% (W / V).

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Abstract

The invention provides a double-cavity packaged vitamin C injection which is stable, safe and convenient for clinical use. In order to achieve the purposes, the technical scheme of the vitamin C injection lies in that the medicinal composition of the double-cavity bagged vitamin C injection comprises the following raw medicine ingredients in parts by weight: 1-3 parts of vitamin C in a powder cavity and a glucose injection or a sodium chloride injection in a solution cavity, wherein in every 100 volume parts, 4-11 weight parts of glucose is contained in the glucose injection, or in every 250 volume parts, 10-27.5 weight parts of glucose is contained in the glucose injection, and in every 100 volume parts, 0.8-1.0 weight part of sodium chloride is contained in the sodium chloride injection, or in every 250 weight parts, 2-2.5 weight parts of sodium chloride is contained in the sodium chloride injection. Meanwhile, the invention also discloses a preparation method for the double-cavity package vitamin C injection.

Description

[0001] technical field [0002] The invention belongs to the technical field of medicine, and relates to a medicine for treating related diseases caused by vitamin C deficiency, in particular to a vitamin C injection packaged in a double-cavity bag. Background technique [0003] Vitamin C injection is a vitamin medicine. Vitamin C participates in amino acid metabolism, synthesis of neurotransmitters, synthesis of collagen and tissue interstitium, can reduce capillary permeability, accelerate blood coagulation, stimulate blood coagulation, promote iron absorption in the intestine, and promote blood lipid drop , increase the resistance to infection, participate in the detoxification function, and have the effect of antihistamine and prevent the formation of carcinogens (nitrosamines). [0004] When 5% glucose solution or 0.9% sodium chloride solution was used as the osmotic pressure regulator, the stability of vitamin C injection was poor. The research found that the content ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/375A61K47/02A61K47/26A61J1/10A61P3/02
Inventor 张德奎胡思玉余启波伏思颖王利春梁隆程志鹏
Owner SICHUAN KELUN PHARMA CO LTD
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