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Ibuprofen slow release solid composition and preparation method thereof

A solid composition and composition technology, which are applied in the directions of drug combination, pharmaceutical formulation, drug delivery, etc., can solve the problems of complex preparation process and poor reproducibility, and achieve simple process, high product yield and good reproducibility. Effect

Inactive Publication Date: 2013-09-04
PEKING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The ibuprofen sustained-release solid pharmaceutical composition has obvious sustained-release properties in vivo and in vitro, and the process is simple, reproducible, and stable, and overcomes the problems of complicated preparation process and poor reproducibility in the prior art. The release solid composition is suitable for industrial production and clinical use

Method used

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  • Ibuprofen slow release solid composition and preparation method thereof
  • Ibuprofen slow release solid composition and preparation method thereof
  • Ibuprofen slow release solid composition and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0027] Embodiment 1, the preparation of ibuprofen sustained-release solid composition

[0028] Weigh 600mg of ibuprofen and add it to 30ml of absolute ethanol, ultrasonically dissolve it fully, add 1800mg of pharmaceutical grade porous silica under magnetic stirring 350, stirred for 12h, removed the solvent; added to 20ml dissolved in 1200mg of acrylic resin In the dehydrated ethanol solution of L100-55, stir for 30min, and then rotary evaporate to dry the solvent, collect the solid part; pass through a 60-mesh sieve after vacuum drying, and obtain the ibuprofen slow-release solid composition.

Embodiment 2

[0029] Embodiment 2, the preparation of ibuprofen sustained-release solid composition

[0030] Weigh 150mg of ibuprofen and add it to 30ml of absolute ethanol, ultrasonically dissolve it fully, add 1800mg of pharmaceutical grade porous silica under magnetic stirring 350, stirred for 12h, removed the solvent; added acrylic resin dissolved in 200mg 20ml of anhydrous ethanol solution of L100-55, stirred for 30min, then rotary evaporated to dry the solvent, and collected the solid part; dried under reduced pressure and passed through a 60-mesh sieve to obtain the ibuprofen sustained-release solid composition.

Embodiment 3

[0031] Embodiment 3, the preparation of ibuprofen sustained-release solid composition

[0032] Weigh 600mg of ibuprofen and add it to 30ml of absolute ethanol, ultrasonically dissolve it fully, add 1800mg of pharmaceutical grade porous silica under magnetic stirring 550, stirred for 12h, removed the solvent; added acrylic resin dissolved in 1800mg 20ml of absolute ethanol solution of L100, stirred for 30min, then rotary evaporated to dry the solvent, and collected the solid part; after drying under reduced pressure, pass through a 60-mesh sieve to obtain the ibuprofen sustained-release solid composition.

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Abstract

The invention relates to an ibuprofen slow release solid composition and a preparation method thereof, in particular to a method for loading ibuprofen into a pore canal by using medicinal grade porous silicon dioxide and coating under the assistance of an acrylic resin. An ibuprofen slow release solid composition prepared with the method has remarkable in-vivo and in-vitro slow release effects; and the preparation method is simple, has high product yield and high repeatability, is easy for industrial production, and has a good development application value.

Description

technical field [0001] The invention relates to an ibuprofen slow-release solid composition and a preparation method thereof, in particular to loading ibuprofen into its pores by using pharmaceutical-grade porous silicon dioxide, and coating it with acrylic ester resin, which belongs to pharmaceutical preparations field. Background technique: [0002] Ibuprofen is a non-steroidal anti-inflammatory drug that has been used clinically for many years. It also has anti-rheumatic, antipyretic and analgesic effects. Its curative effect and side effects are superior to aspirin and acetaminophen. It is clinically used for the long-term treatment of rheumatic and acute rheumatoid arthritis, and can also be widely used for the treatment of various moderate pain, inflammation, fever and other diseases. The biological half-life of ibuprofen is short (1.8-2h), and its common preparations currently on the market in China require frequent administration. However, long-term medication can ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/192A61K47/32A61K47/04A61K9/00A61P29/00
Inventor 张强代文兵李林青
Owner PEKING UNIV
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