Preparation method of high-purity propofol

Abstract

The invention discloses a preparation method of high-purity propofol. The method comprises the steps shown below, wherein R is selected from chlorine, bromine or sulfonate. The method provided by the invention is advantaged in intelligent idea, simple process, and suitability for industrialized productions. The purity of the prepared propofol is above 99.9%, and the prepared propofol satisfies various medical pharmaceutical standards.

Description

technical field The invention belongs to the technical field of chemical pharmacy and relates to a preparation method of high-purity propofol. Background technique Propofol (chemical name: 2,6-diisopropylphenol) is a new fast and short-acting intravenous anesthetic commonly used clinically for induction of anesthesia, maintenance of anesthesia, and sedation of critically ill ICU patients. It has Anesthesia induction has quick onset, rapid recovery and complete functional recovery, and a low incidence of postoperative nausea and vomiting. In the traditional synthesis process, the preparation method of propofol is to use aluminum phenate as a catalyst, and then carry out the alkylation reaction of phenol and propylene under the conditions of high temperature and high pressure. Since the reaction needs to be carried out under the condition of high temperature and high pressure, and the exotherm is severe, it is difficult to control the reaction accurately. Therefore, the pro...

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Problems solved by technology

The Chinese patent with the publication number CN101538191 discloses a synthesis method of high-purity propofol, using 2-isopropylphenol and propylene as raw materials, catalyzed by Lewis acids such as triethylaluminum, and reacting at a pressure of 0.4-0.6Mpa to synthesize High-purity propofol, but its highest purity is only 92.7%, and the purity of raw material 2-isopropylphenol is required to be more than 99%; the U.S. patent application with publication number US5589598 discloses a high-purity propofol preparation method , acylate propofol to obtain a solid ester, after purification, then hydrolyze and distill under reduced pressure to obtain propofol with a purity of more than 99%. , acid chloride is sensitive to moisture and corrosive to equipment