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Medicine composition of cycloartenyl ferulate

A technology of pineapplenol ferulic acid ester and composition, which is applied in the field of medicine, and can solve the problems of low solubility and inability to solve the problem that cycloartenyl ferulic acid ester is difficult to dissolve in water, etc.

Inactive Publication Date: 2012-10-31
BEIJING CENTURY BIOCOM PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the research on the pure product of cycloartenol ferulate, the applicant found that its solubility in water is lower than that of oryzanol raw material, only about 1 / 3 of the solubility of oryzanol. The traditional technology used to solve the solubilization of oryzanol None of the schemes can solve the insoluble problem of cycloartenyl ferulic acid ester

Method used

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  • Medicine composition of cycloartenyl ferulate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take 40g of s6, heat it to a molten state at 60°C, then add 8g of cycloartenyl ferulic acid ester to it, mix and stir for 15min, add the resulting molten liquid into 5L of water for injection and stir until it is completely dissolved. The pharmaceutical composition of the invention has a concentration of 1.6 mg / ml.

[0031] The resulting solution cleared completely on standing at room temperature for 24 hours.

Embodiment 2

[0033] Take 100g of S20, heat it to a molten state at 60°C, then add 10g of cycloartenyl ferulic acid ester to it, mix and stir for 30min, add the resulting molten liquid into 5L of water for injection and stir until it is completely dissolved. The inventive pharmaceutical composition has a concentration of 2 mg / ml.

[0034]The resulting solution cleared completely on standing at room temperature for 24 hours.

Embodiment 3

[0036] Take 200g of s40, heat it to a molten state at 70°C, then add 5g of cycloartenyl ferulic acid ester to it, mix and stir for 40min, add the resulting molten liquid into 4L of water for injection and stir until it is completely dissolved. The pharmaceutical composition of the invention has a concentration of 1.25mg / ml.

[0037] The resulting solution cleared completely on standing at room temperature for 24 hours.

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Abstract

The invention discloses a medicine composition of cycloartenyl ferulate. The medicine composition solves the problem that the cycloartenyl ferulate cannot dissolve in water easily and contains cycloartenyl ferulate and polyoxyl stearate. Stable and water-soluble oryzanol medicine composition solution is obtained by adding the cycloartenyl ferulate into the molten polyoxyl stearate. The invention further discloses a preparation method and preparation application of the medicine composition of cycloartenyl ferulate.

Description

[0001] [0002] This application is a divisional application of the Chinese invention patent application with application number 201110004417.1. technical field [0003] The invention discloses a pharmaceutical composition of cycloartenol ferulate, which comprises cycloartenol ferulate and polyoxyl stearate, and belongs to the field of medicine. Background technique [0004] Oryzanol is a natural mixture composed of cycloartenol ferulic acid esters and sterol ferulic acid esters. The main two components are cycloartenol ferulic acid esters and 24 - Methyl cycloartenol ferulate, the content of the two in unpurified oryzanol is about 70%, and it is the main active ingredient in oryzanol. Long-term studies have found that oryzanol has a variety of pharmacological activities, such as lowering blood lipids, lowering cholesterol absorption, preventing lipid oxidation, preventing cardiovascular diseases, alleviating various physical obstacles and autonomic nervous disorders in wom...

Claims

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Application Information

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IPC IPC(8): A61K31/575A61K47/34A61P3/06A61P9/00A61P15/12A61P25/00
Inventor 郝守祝
Owner BEIJING CENTURY BIOCOM PHARMA TECH
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