Degradable submicron fiber membrane for postoperative adhesion prevention and preparation thereof

A biodegradable and dimethyl sulfoxide technology, which is applied in the field of implanting three types of medical devices, can solve the problems of unfavorable long-term production, low pH value, and unstable solvent system, etc., and achieve the effect of long-term high-speed production

Inactive Publication Date: 2012-10-31
SHENZHEN FEIXIANG SHIJI BIOLOGICAL
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

The products produced by the improved technology have the following disadvantages: 1. The product is impermeable and airtight; 2. Residual toxic solvents; 3. The self-catalytic degradation process leads to local low pH value, which triggers an inflammatory response
However, the existing electrospinning technology has the following disadvantages: the reported solvent system that meets the safety standards is not stable enough, it is easy to block the needle, and it is not conducive to industrialized long-term production

Method used

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  • Degradable submicron fiber membrane for postoperative adhesion prevention and preparation thereof
  • Degradable submicron fiber membrane for postoperative adhesion prevention and preparation thereof
  • Degradable submicron fiber membrane for postoperative adhesion prevention and preparation thereof

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Experimental program
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Embodiment 1

[0027] The solvent was a mixture of chloroform and methanol (8:2 v / v), PLLA raw material (Purac, average molecular weight 200000). The polymer concentration was 40 mg / ml.

[0028] The electrospinning solution was stored in a needle, and the spinning solution was extruded from a 27-gauge needle by a needle pump. Outflow rate 5ml / hr. Apply a voltage of 7kV through a high-voltage direct current generator, and the distance from the needle to the collecting plate is 12cm (see attached Figure 1 ). The spinning process takes 1 hour, and a piece of fiber film with a size of 15×15 cm and an average thickness of 50 microns can be made, vacuumized to remove residual solvent, packaged and sterilized.

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Abstract

The invention relates to a degradable non-woven submicron fiber membrane and a preparation method thereof, as well as a purpose thereof for postoperative adhesion prevention of tissues and organs. A textile is prepared by adopting an electrostatic spinning method. The fiber membrane prepared by the method has good flexibility, air permeability and an effective tissue cell isolation function. A submicron structure with high specific surface area is also conductive to fast and uniform degradation of fiber. The fiber membrane after sterilization treatment can be used as a postoperative anti-adhesion membrane.

Description

technical field [0001] The present invention "a degradable submicron fiber film for postoperative anti-adhesion and its preparation" belongs to the implantation of three types of medical devices, and is used as postoperative anti-adhesion film. Background technique [0002] Postoperative adhesion is one of the unresolved problems in surgery. In theory, almost all operations involve the problem of adhesion between tissues. It can cause serious complications, such as the formation of adhesions in the abdominal cavity can cause complications such as adhesive ileus, pelvic pain and female infertility, postoperative epilepsy due to local adhesions after cranial surgery, and postoperative epilepsy due to local adhesions after cranial surgery. And secondary recurrent laryngeal nerve injury. Although most patients can be relieved by non-surgical treatment, it is easy to relapse and cannot be cured, which affects the quality of life. For patients with adhesive intestinal obstructio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01D1/02D01D5/00D04H1/728D04H1/435
Inventor 董毅翔
Owner SHENZHEN FEIXIANG SHIJI BIOLOGICAL
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