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Venlafaxine hydrochloride sustained release capsule and preparation method thereof

A technology of venlafaxine hydrochloride and sustained-release capsules, which can be applied to medical formulas, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc., and can solve the problems of expensive sustained-release materials and high production costs of medicines , to achieve the effect of stable material, easy control, low flammability and good film formation

Active Publication Date: 2012-11-14
LEPU HENGJIUYUAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent 200910162006.8, patent name: Venlafaxine Hydrochloride Sustained-release Pellet Capsules Sustained-release coating film adopts polyacrylic acid resin, the sustained-release material is expensive, and the cost of drug production is high

Method used

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  • Venlafaxine hydrochloride sustained release capsule and preparation method thereof
  • Venlafaxine hydrochloride sustained release capsule and preparation method thereof
  • Venlafaxine hydrochloride sustained release capsule and preparation method thereof

Examples

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Embodiment 1

[0018] A venlafaxine sustained-release capsule, the content of the sustained-release capsule is sustained-release pellets, the sustained-release pellets from inside to outside are pellet core, isolation layer, sustained-release layer, pellet core, isolation layer, Sustained-release layer prescriptions are shown in Table 1-1, Table 1-2, and Table 1-3.

[0019]

[0020]

[0021]

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PUM

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Abstract

The invention belongs to the field of pharmaceutical preparations, and discloses a venlafaxine hydrochloride sustained release capsule and a preparation method thereof. The content of the sustained release capsule is a sustained release micro pill, wherein the sustained release pill is successively provided with a pill core, an isolating layer and a sustained release layer from the interior to the exterior, the pill core is prepared from the following constituents according to weight percentage composition: 45-48% of venlafaxine hydrochloride, 15-18% of bulking agent, 3-3.5% of disintegrating agent, 4-6% of povidone K 30, 24-26% of absolute ethyl alcohol and the balance being water; the isolating layer is prepared from the following constituents according to weight percentage composition: 11-13% povidone K30, 83-86% of absolute ethyl alcohol and the balance being talcum powder; the sustained release layer is prepared from the following constituents according to weight percentage composition: 38-42% of ethocel suspension, 0.1-1.0% of polyethylene glycol-60000 and the balance being water, wherein the ethocel accounts for 20-30% of the ethocel suspension in mass; and the preparation method provided by the invention has the following steps of preparing the pill core, packing the isolating layer, packing the sustained release layer and filling a capsule, thus obtaining the sustained release capsule. The venlafaxine hydrochloride sustained release capsule provided by the invention adopts the ethocel, the flammability is low, the hygroscopicity is small, good film formation property can be achieved, the material is stable and is easy to control, and the venlafaxine hydrochloride sustained release capsule is safe and environment-friendly.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a venlafaxine hydrochloride sustained-release capsule and a preparation method thereof. Background technique [0002] Venlafaxine hydrochloride is an effective anxiolytic and antidepressant. It exists in the form of hydrochloride in the medicament. Its chemical name is: (±)-1-[2-(dimethylamino)-1- (4-Methoxyphenyl) ethyl] cyclohexanol hydrochloride, the chemical structural formula is as follows: [0003] . [0004] Venlafaxine is an ethylamine derivative and is a dual inhibitor of norepinephrine and serotonin reuptake. It has been used in the first-line treatment of depression, mainly for various types of depression, including depression accompanied by anxiety. and generalized anxiety disorder. [0005] U.S. Wyeth Corporation patent application number: 97109594.9, patent name: sustained-release preparation, wherein organic solvents such as dichloromethan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K31/137A61K47/38A61P25/22A61P25/24
Inventor 张克军王庆鹏马可鸿梁猛孙冬梅
Owner LEPU HENGJIUYUAN PHARMA CO LTD
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