Preparation method of zingiber corallinum hance essential oil/hydroxypropyl-beta-cyclodextrin clathrate and preparation method of zingiber corallinum hance essential oil/hydroxypropyl-beta-cyclodextrin clathrate injection

A technology of cyclodextrin inclusion compound and coral ginger essential oil, which is applied in the direction of non-active ingredients of polymer compounds, medical preparations containing active ingredients, drug delivery, etc., and can solve problems such as volatile, decreased volatile oil content, and impact on product quality, etc. problem, achieve the effect of avoiding volatilization and maintaining content

Inactive Publication Date: 2013-01-02
重庆灵方生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But because coral ginger essential oil has very strong volatility like most essential oils, and the preparation that contains volatile oil, because volatile oil stability is poor, easily volatilizes, often causes the volatile oil content in the medicine in the valid period to decline, affects product quality, also makes simultaneously Clinical efficacy is not guaranteed
At present, the preparation methods for volatile oil in the production of traditional Chinese medicine mainly include three methods: crushing the medicinal material containing volatile oil and directly using it as medicine, directly spraying the volatile oil after extraction, and using cyclodextrin inclusion technology as medicine. The first two methods are volatile oil used as medicine The stability of the volatile oil is poor, especially the stability of the volatile oil sprayed into the volatile oil after extraction is the worst, and the stability of the volatile oil is improved after being treated with cyclodextrin inclusion technology

Method used

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  • Preparation method of zingiber corallinum hance essential oil/hydroxypropyl-beta-cyclodextrin clathrate and preparation method of zingiber corallinum hance essential oil/hydroxypropyl-beta-cyclodextrin clathrate injection
  • Preparation method of zingiber corallinum hance essential oil/hydroxypropyl-beta-cyclodextrin clathrate and preparation method of zingiber corallinum hance essential oil/hydroxypropyl-beta-cyclodextrin clathrate injection

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Experimental program
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Effect test

Embodiment 1

[0017] Embodiment 1: Get 4 times of coral ginger essential oil weight of hydroxypropyl-β-cyclodextrin and dissolve it in water for injection of 15 times of coral ginger essential oil weight, get coral ginger essential oil and dissolve it in anhydrous methanol to make a solution, and hydroxypropyl -After stirring and mixing the β-cyclodextrin solution and the coral ginger essential oil solution, they were stirred and clathrated in a water bath at 80°C for 2 hours, cooled to room temperature, and filtered through a filter membrane to obtain coral ginger essential oil / hydroxypropyl-β-cyclodextrin Aqueous clathrate solution.

Embodiment 2

[0018] Embodiment 2: Get 7 times of coral ginger essential oil weight of hydroxypropyl-β-cyclodextrin and dissolve it in water for injection of 10 times of coral ginger essential oil weight, get coral ginger essential oil and dissolve it in absolute ethanol to make a solution, and hydroxypropyl After stirring and mixing the base-β-cyclodextrin solution and the coral ginger essential oil solution, they were stirred and clathrated in a water bath at 60°C for 15 hours, cooled to room temperature, and filtered through a filter membrane to obtain coral ginger essential oil / hydroxypropyl-β-cyclodextrin Aqueous clathrate solution.

Embodiment 3

[0019] Embodiment 3: Get the hydroxypropyl-beta-cyclodextrin of 5 times coral ginger essential oil weight and be dissolved in the injection water of 12 times coral ginger essential oil weight, get coral ginger essential oil and dissolve in the mixed solvent of absolute methanol and absolute ethanol to prepare To form a solution, mix the hydroxypropyl-β-cyclodextrin solution and the coral ginger essential oil solution, stir and mix them in a water bath at 70°C for 15 hours, cool to room temperature, and filter through a membrane to obtain coral ginger essential oil / hydroxypropyl ginger Base-β-cyclodextrin inclusion complex aqueous solution.

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Abstract

The invention relates to a preparation method of a zingiber corallinum hance essential oil/hydroxypropyl-beta-cyclodextrin clathrate and a preparation method of a zingiber corallinum hance essential oil/hydroxypropyl-beta-cyclodextrin clathrate injection. The preparation method of the zingiber corallinum hance essential oil/hydroxypropyl-beta-cyclodextrin clathrate comprises the following steps of weighing hydroxypropyl-beta-cyclodextrin of which the weight is 4-7 times the weight of zingiber corallinum hance essential oil, dissolving zingiber corallinum hance essential oil into absolute methanol or absolute DMF or absolute 1,4-dioxane to obtain a zingiber corallinum hance essential oil solution, mixing the zingiber corallinum hance essential oil solution and the hydroxypropyl-beta-cyclodextrin solution by stirring, carrying out stirring clathration in a water-bath having a temperature of 40 to 80 DEG C for 2 to 20 hours, cooling to a room temperature, and filtering by a filter membrane to obtain a zingiber corallinum hance essential oil/hydroxypropyl-beta-cyclodextrin clathrate aqueous solution. The preparation method of the zingiber corallinum hance essential oil/hydroxypropyl-beta-cyclodextrin clathrate injection comprises the following step of diluting the zingiber corallinum hance essential oil/hydroxypropyl-beta-cyclodextrin clathrate aqueous solution by injection water into the zingiber corallinum hance essential oil/hydroxypropyl-beta-cyclodextrin clathrate injection having a required concentration. The zingiber corallinum hance essential oil/hydroxypropyl-beta-cyclodextrin clathrate and the zingiber corallinum hance essential oil/hydroxypropyl-beta-cyclodextrin clathrate injection avoid volatilization and oxidation deterioration of zingiber corallinum hance essential oil, and can stabilize zingiber corallinum hance essential oil content.

Description

technical field [0001] The invention relates to the field of pharmaceutical technology, in particular to a coral ginger essential oil / hydroxypropyl-β-cyclodextrin inclusion compound and a preparation method thereof. Background technique [0002] Coral ginger is the rhizome of Zingiberaceae. Its plant morphology, medicinal properties, microscopic characteristics, physical and chemical identification, thin-layer chromatography and ultraviolet absorption spectrum have its unique identification characteristics. The basis for the development of standards is provided. Coral ginger is one of the commonly used medicinal materials in Dai medicine, and it is also a folk custom in Yunnan, Guizhou and other regions. Its taste is bitter, cold in nature, and enters the earth pagoda. It has the functions of invigorating the stomach and eliminating accumulation. It is used to treat symptoms such as food accumulation, fullness, abdominal pain, nausea and vomiting, hepatosplenomegaly and h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K47/40A61K9/08A61P31/04
Inventor 陈春林王建华唐京生胡仕林
Owner 重庆灵方生物技术有限公司
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