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Application of icariin to preparation of medicament for treating bronchial asthma

A technology of bronchial asthma and icariin, applied in the field of icariin in the preparation of drugs for the treatment of bronchial asthma, and the promotion of apoptosis of asthmatic eosinophils in the treatment of bronchial asthma

Inactive Publication Date: 2013-01-23
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, there has been no report on the use of icariin in promoting the apoptosis of asthmatic eosinophils, especially in the treatment of bronchial asthma by promoting the apoptosis of asthmatic eosinophils

Method used

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  • Application of icariin to preparation of medicament for treating bronchial asthma
  • Application of icariin to preparation of medicament for treating bronchial asthma
  • Application of icariin to preparation of medicament for treating bronchial asthma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Effect of icariin on apoptosis of eosinophils in asthmatic mice

[0036] Materials and Methods:

[0037] 1 drug icariin, using DMSO to aid dissolution.

[0038] 2 modeling method

[0039] Groups B to F: On the 1st and 8th days, intraperitoneally inject 0.5ml of a suspension containing 100ug of OVA and 0.5ml of aluminum hydroxide gel; from the 15th day onwards, inhalation of 1% ovalbumin normal saline solution for 30 minutes stimulates asthma , once every other day, for 6 consecutive weeks; normal control group (group A): the same amount of normal saline was used instead of ovalbumin for intraperitoneal injection and aerosol inhalation.

[0040] 3. Administration method

[0041] All groups were administered from the 15th day, intraperitoneal injection 1 hour before each nebulization inhalation challenge, once every other day, for a total of 6 weeks. Estimate the dosage of experimental animals according to the clinical dosage of human. Icariin low, medium a...

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Abstract

The invention belongs to the field of Chinese medicine pharmacy, and relates to an application of icariin to preparation of a medicament for treating bronchial asthma, in particular to treatment of bronchial asthma with icariin by prompting eosinophilic granulocyte apoptosis. As proved by the result of an influence experiment of eosinophilic granulocyte apoptosis of a mouse suffering from bronchial asthma, the icariin influences intrapulmonary eosinophilic granulocyte apoptosis of the mouse suffering from bronchial asthma and expression of relevant gene proteins Bc1-2 and Bax, and can be used for promoting asthmatic eosinophilic granulocyte apoptosis, reducing asthmatic air channel eosinophilic granulocyte infiltration and influencing the expression of apoptosis-relevant gene proteins Bcl-2 and Bax to achieve the effect of treating bronchial asthma. The icariin can be a medicinal composition for treating bronchial asthma prepared from active ingredients and pharmaceutically-acceptable carriers.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to the new medical application of icariin, in particular to the application of icariin in the preparation of medicines for treating bronchial asthma, especially the treatment of bronchial asthma by promoting the apoptosis of asthmatic eosinophils. Background technique [0002] Studies have reported that eosinophils are the main effector cells in the pathogenesis of eosinophilic asthma; activated eosinophils can release a variety of active substances, such as major basic protein (MBP), eosinophilic cationic protein (ECP) , eosinophil protein X (EPX), eosinophil-derived neurotoxin (EDN), eosinophil peroxidase (EPO), platelet activating factor (PAF), etc.; which can cause a series of tissue damage, Such as epithelial cell defect, plasma extravasation, airway hyperresponsiveness and initiation and maintenance of tissue inflammation. In addition, eosinophils may also h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P11/06
Inventor 董竞成杜文静蔡萃吴金峰刘宝君曹玉雪
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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