Application of thais clavigera to preparation of antipyretic and anti-inflammatory medicine

The technology of an anti-inflammatory drug and lychee snail is applied in the field of medicine, which can solve the problems of low adverse reactions and the like, and achieve the effects of low adverse reactions, significant drug effects, and good antipyretic and anti-inflammatory activities.

Inactive Publication Date: 2013-01-30
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Purpose of the invention: The technical problem to be solved by this invention is to make full use of marine resources and develop antipyretic and anti-inflammatory drugs with good effect and low adverse reactions

Method used

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  • Application of thais clavigera to preparation of antipyretic and anti-inflammatory medicine
  • Application of thais clavigera to preparation of antipyretic and anti-inflammatory medicine
  • Application of thais clavigera to preparation of antipyretic and anti-inflammatory medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] 1. Preparation of lychee snail soft body extract: take lychee snail meat and lychee snail shell, add 2 to 3 times the amount of lychee snail meat to homogenate at 10,000 rpm for 3 times, each time for 30 seconds , to obtain a homogenate, extract at 4°C to obtain a filtrate, stand still, centrifuge to obtain a supernatant, and freeze-dry at -66°C to obtain final product;

[0017] 2. Preparation of lychee snail shell powder: take lychee snail shell, wash, crush, and pass through a 100-mesh sieve.

Embodiment 2

[0018] Example 2 Evaluation of antipyretic activity of snails

[0019] 1. Experimental group:

[0020] Rats with a body weight of 200-250 g, 40 rats with a body temperature range of 36.0-38.5°C and body temperature fluctuations less than 0.5°C were randomly divided into blank group, model group, and positive drug group (aspirin 80 mg / kg). Litchi snail soft body extract group (0.35 g / ml) prepared in Example 1, and Litchi snail shell powder group (0.6 g / ml) prepared in Example 1, 8 in each group. Rectal temperature was measured twice before modeling, and the measured body temperature was used as "basal body temperature". Rats in each group were subcutaneously injected with 20% yeast-NS solution 10 ml / kg in the back to create a fever model. Six hours after modeling, the rats in each group were intragastrically administered with a dosage of 5 ml / kg. Retest the anal temperature of the rats at 0 h, 0.5 h, 1 h, 1.5 h, 2 h, 2.5 h, and 3 h after administration. Observe the change t...

Embodiment 3

[0030] Example 3 Evaluation of anti-inflammatory activity of snails

[0031] 1. Xylene-induced mouse auricle swelling experiment (mouse ear swelling method)

[0032] Get 60 mice, be divided into 7 groups at random, namely blank control (normal saline) group, model group, aspirin group, the litchi snail soft body extract dosage group (0.07576 g / ml) prepared by the embodiment 1 of the present invention and low Dose group (0.01894 g / ml), high-dose group (1.8020 g / ml) and low-dose group (0.4505 g / ml) of litchi snail shell powder prepared in Example 1 of the present invention, 10 in each group. Intragastric administration for 3 consecutive days, the administration volume was 0.1 ml / 10 g, 1 hour after the last administration, 0.05 ml of xylene was evenly applied to both sides of the right ear of the mouse, and the left ear was not applied as a control, for 40 minutes Mice were sacrificed by cervical dislocation, and ear pieces were punched at the same position in both ears with an ...

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Abstract

The invention discloses application of thais clavigera to the preparation of an antipyretic and anti-inflammatory medicine. The pharmacological activity of the thais clavigera is screened through a lot of experiments; and experimental results show that a soft body extract of the thais clavigera or shell powder of the thais clavigera has a strong effect of inhibiting acute inflammation models of mouse ear swelling caused by dimethylbenzene and mouse pedal swelling caused by carrageenan, shows good antipyretic and anti-inflammatory activities, also has the antioxidant capacity, and can strengthen the activity of superoxide dismutase (SOD), eliminate oxygen free radicals, and reduce the release of malondialdehyde. The thais clavigera has an important significance for fully utilizing vast ocean resources and developing novel safe and effective marine medicines.

Description

technical field [0001] The invention relates to a medicine, in particular to the new application of marine organism snail snail in the preparation of antipyretic and anti-inflammatory medicine. Background technique [0002] According to the "Chinese Materia Medica", the snail is a mollusk of the family Murexaceae, also known as the spicy snail. The morphological characteristics: the shell is oval, generally 33mm high and 21mm wide, with verrucous protrusions on the shell surface. dark grey. Sexual taste function: salty, flat. Ruanjian Sanjie, attending cervical lymph node tuberculosis, goiter. There is no antipyretic and anti-inflammatory report yet. Therefore, in order to make full use of the vast ocean resources and develop new marine medicines, it is very necessary to develop new uses of snails on the technology of the prior art. Contents of the invention [0003] Purpose of the invention: The technical problem to be solved by this invention is to make full use of m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/56A61P29/00A61K35/618
Inventor 唐于平刘欣段金廒刘睿郭建明丁少雄林祥志林汝榕
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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