The invention discloses a method for brewing cucumis metuliferus fruit wine. According to the method, fresh cucumis metuliferus is adopted as a main raw material, polygonatum odoratum is added as an adjuvant, and the fruit wine is prepared through the steps of carrying out raw material screening, carrying out cleaning, carrying out raw material pretreatment, carrying out sweetness and acidity regulating, carrying out fermenting, carrying out mixing, carrying out blending, carrying out filtering, carrying out pouring and carrying out packaging. According to the method, cucumis metuliferus serves as the main raw material, polygonatum odoratum serves as the adjuvant, traditional Chinese medicine ingredients such as white snail shells, Scirpus triqueter, Drymoglossum bones, Cassiope selaginoides, Yunnan alpinia henryi, Litsea coreana, radix scutellariae, radix paeoniae alba, dandelion, Begonia yunnanensis and the like are added, nutritive values of cucumis metuliferus and polygonatum odoratum are fully utilized, and the used raw materials and the added traditional Chinese medicine ingredients are in synergy, so that the fruit wine prepared by the method has original nutritional ingredients of the raw materials, has the healthcare effects of warming the middle-jiao and strengthening the spleen and regulating Qi and nourishing the stomach and is beneficial to human health; and the preparation method is scientific and feasible and is high in operability, and the finished product fruit wine is golden-yellow or pale-yellow, is mellow, fresh and lasting-sweet in wine taste, faint-fragrant in flavor, coexisting in liquor fragrance and fruit fragrance and has a remarkable economic value.