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A kind of water-based compound camel seed pharmaceutical composition and preparation method thereof

A composition and camel technology, applied in the directions of drug combinations, antipyretics, pharmaceutical formulations, etc., can solve the problems of hindering skin sweating and heat dissipation, affecting the treatment effect, patient discomfort, etc., to improve the curative effect, enhance the clinical curative effect, Good coupling effect

Active Publication Date: 2018-08-03
HEFEI YIFAN PHARMA MANAGEMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The ointment preparation of this drug is a relatively oily product, and the therapeutic effect is relatively obvious in the cold winter, but in the hot summer, because the skin secretes more oil, plus the oil of the drug will block the pores of the skin and cause skin irritation. Inflammation, but also hinder skin sweating and heat dissipation, giving patients an uncomfortable feeling and affecting the therapeutic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] According to the composition of the formula: 20% of camel's cape seed; 12% of angelica; 8% of colchicum; 6% of cetearyl alcohol; 3% of white petrolatum; 10% of liquid paraffin; 4% of glyceryl monostearate; Ethyl p-hydroxybenzoate 0.1%; Glycerin 16%; Sodium lauryl sulfate 1%; Purified water 19.9%, put the camel seed, angelica, and colchicum into the pulverizer, and start the pulverizer to pulverize into fine powder , take the pulverized camel cape seed, angelica, colchicum fine powder, heat and reflux for extraction 2 times, add 95% ethanol (hydrochloric acid to adjust the pH value to 4) of 5 times the amount of medicinal materials each time, and reflux for 3 hours each time, Combine the extracts, let stand, filter (200 mesh sieve) to obtain the filtrate, take the filtrate to recover ethanol, concentrate to extract (no alcohol smell) with a relative density of 1.25-1.30 (20°C); take the oil phase 16. Stearyl alcohol, white vaseline, liquid paraffin, glyceryl monostearate...

Embodiment 2

[0032] According to the composition of the formula: 19.5% of camel cape seed; 11.5% of celestial fairy; 9% of colchicum; 6% of cetearyl alcohol; 3% of white petrolatum; 10% of liquid paraffin; 4% of glyceryl monostearate; Ethyl p-hydroxybenzoate 0.1%; Glycerin 16%; Sodium lauryl sulfate 1%; Purified water 19.9%, put the camel seed, angelica, and colchicum into the pulverizer, and start the pulverizer to pulverize into fine powder , take the pulverized camel cape seed, angelica, colchicum fine powder, heat and reflux for extraction 2 times, add 95% ethanol (hydrochloric acid to adjust the pH value to 4) of 5 times the amount of medicinal materials each time, and reflux for 3 hours each time, Combine the extracts, let stand, filter (200 mesh sieve) to obtain the filtrate, take the filtrate to recover ethanol, concentrate to extract (no alcohol smell) with a relative density of 1.25-1.30 (20°C); take the oil phase 16. Stearyl alcohol, white vaseline, liquid paraffin, glyceryl mon...

Embodiment 3

[0034] According to the composition of the formula: 21.5% of camel's seed; 10.5% of Heliconia; 6.5% of colchicum; 6.0% of cetearyl alcohol; 3.5% of white petrolatum; 11.0% of liquid paraffin; 3.5% of glyceryl monostearate; Ethyl p-hydroxybenzoate 0.05%; Glycerin 15.5%; Sodium lauryl sulfate 1.5%; Take the fine powder of camel's cape seed, angelica, and colchicum, heat and reflux for extraction twice, add 5 times the amount of 95% ethanol (hydrochloric acid to adjust the pH value to 4) each time, extract by reflux for 3 hours each time, and combine Extract, let stand, filter (200 mesh sieve) to obtain filtrate, take filtrate to recover ethanol, concentrate to extract (no alcohol smell) with relative density of 1.25~1.30 (20°C); take oil phase 16.10 Octanol, white petrolatum, liquid paraffin, glyceryl monostearate, heated to about 100°C, and kept warm for 30 minutes. After the keep warm, put ethyl p-hydroxybenzoate into the oil phase dissolving pot until completely dissolved, Coo...

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Abstract

The invention relates to a water-based compound medicinal composition of camel's seed and a preparation method thereof, which is prepared from the following prescriptions: 19.0%-21.5% of camel's seed; 10.5.0%-13.5% of angelica; 6.5% of colchicum ‑9.0%; Cetostearyl Alcohol 5.5%‑8.0%; White Petrolatum 1.5%‑3.5%; Liquid Paraffin 9.5%‑11.0%; Glyceryl Monostearate 3.5%‑4.5%; Ester 0.05%‑0.15%; Glycerin 15.5%‑17.5%; Sodium Lauryl Sulfate 0.5%‑1.5%; Purified Water 18.4%‑20.4%. The pharmaceutical composition of the present invention mainly treats joint pain, rheumatoid arthritis, sciatica, eczema and other diseases caused by dampness and cold, and has good stability, good infiltration, good transdermal effect, less toxic and side effects, and less irritation , high safety, simple preparation, low cost, obvious effect and easy popularization.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a water-based compound camel cape seed cream and a preparation method thereof. Background technique [0002] Arthralgia, rheumatoid arthritis, sciatica, eczema, scabies, scabies, etc. caused by dampness and cold often appear clinically, the treatment cycle is long, recurrence is easy, and it is an intractable disease. There are many kinds of medicines for joint pains, rheumatoid arthritis, sciatica, eczema, scabies, scabies, etc. caused by damp and cold in the market. There are western medicines, traditional Chinese medicines, and mixed Chinese and western medicines. But some side effects are relatively large or the effect is not ideal, and the treatment course is long, requiring long-term use. The curative effect of the external plaster used at present is not obvious after use, and can only play the effect of temporary pain relief. [0003] Peganum harmala L. has a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/896A61K9/06A61P17/00A61P19/02A61P29/00
Inventor 程先锋
Owner HEFEI YIFAN PHARMA MANAGEMENT