Pharmaceutical composition of 12 complex vitamins for injection and preparation method thereof

Abstract

The invention provides a pharmaceutical composition of 12 complex vitamins for injection and a preparation method thereof. The pharmaceutical composition of 12 complex vitamins for injection provided by the invention comprises the active ingredients of vitamin A palmitate, cholecalciferol, racemic alpha-tocopherol, ascorbic acid, nicotinamide, dexpanthenol, pyridoxine hydrochloride, riboflavin sodium phosphate, tetrahydrate thiamine pyrophosphate, folic acid, D-biotin and cyanocobalamin, and auxiliary materials namely polysorbate 80 and mannitol. The prescription provided by the invention does not contain auxiliary material glycocholic acid, and can be clinically used for people with over-high glycocholic acid.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to 12 compound vitamin pharmaceutical compositions for injection and a preparation method thereof Background technique [0002] 12 multivitamins for injection, the active ingredients are vitamin A palmitate, cholecalciferol, racemic α-tocopherol, ascorbic acid, niacinamide, dexpanthenol, pyridoxine hydrochloride, riboflavin sodium phosphate, tetrahydrate Thiamine pyrophosphate, folic acid, D-biotin, cyanocobalamin. This product is an intravenous vitamin supplement. [0003] This product is suitable for children over 11 years old and adults receiving parenteral nutrition multivitamin daily dosage and routine intravenous requirement in other situations, including surgery, extensive burns, fractures and other traumas, severe infectious diseases and coma. It can be used for the emergency response of the body's metabolism and the lack of tissue nutrition under continuous sev...

AI Technical Summary

Problems solved by technology

[0008] Glycocholic acid and soybean phospholipids are indeed good solubilizers, and have a good solubilizing effect on 12 kinds of multivitamins for injection. However, glycocholic acid is a physiologically active substance, and it also has its shortcomings. The 12 kinds of multivitamins for injection of glycocholic acid are not suitable for people with high glycocholic acid, especially pregnant women. High glycocholic acid is cholestasis, which is a complication of many pregnant women in the middle and late stages of pregnancy. , Pregnant women are high in glycocholic acid, which has no effect on the pregnant woman itself, but has a great impact on the fetus. It is likely to cause fetal asphyxia, and it may also cause fetal asphyxia during childbirth. It should be taken seriously

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