Pharmaceutical composition for treating malignant tumors and preparation method thereof
A composition and drug technology, applied in drug combinations, anti-tumor drugs, pharmaceutical formulations, etc., can solve the problems of different and different drug effects, and achieve the effects of prolonging survival, shrinking tumors, and inhibiting death.
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Embodiment 1
[0061] Formulation Example 1: The preparation of granules of the present invention
[0062] Prescription: Poria 4000g, Arctium 1500g, Hedyotis diffusa 400g, Banzhilian 600g, Achyranthes bidentata 1200g, atorvastatin calcium 0.4g.
[0063] Preparation Process:
[0064] 1) Weigh Hedyotis diffusa, Scutellaria barbata, Poria cocos, Arctium, Achyranthes bidentata according to the above prescription, dry and crush them through an 80-mesh sieve, add 8 times the amount of ethanol to reflux and extract twice, each time for 4 hours, combine the extracts, filter After that, the ethanol was recovered under reduced pressure and concentrated to a thick paste, and dried in vacuo to obtain the ethanol extract;
[0065] 2) Take the dregs after alcohol extraction in step 1, add 8 times the amount of water to decoct twice, 4 hours each time, combine the decoction, concentrate the filtrate under reduced pressure to a relative density of 1.15-1.20, and vacuum dry to obtain the water extract;
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Embodiment 2
[0067] Preparation Example 2: The preparation of granules of the present invention
[0068] Prescription: Poria 5000g, Arctium 1500g, Hedyotis diffusa 300g, Banzhilian 400g, Achyranthes bidentata 1800g, atorvastatin calcium 0.6g.
[0069] Preparation Process:
[0070] 1) Weigh Hedyotis diffusa, Scutellaria barbata, Poria cocos, Burdock fruit, and Achyranthes bidentata according to the above prescription, dry and crush them through an 80-mesh sieve, add 10 times the amount of ethanol to reflux and extract twice, each time for 2 hours, combine the extracts, filter After that, the ethanol was recovered under reduced pressure and concentrated to a thick paste, and dried in vacuo to obtain the ethanol extract;
[0071] 2) Take the medicinal residue after alcohol extraction, add 10 times the amount of water to decoct twice, 2 hours each time, combine the decoction, concentrate the filtrate under reduced pressure to a relative density of 1.15-1.20, and vacuum dry to obtain the wat...
Embodiment 3
[0073] Preparation Example 3: The preparation of granules of the present invention
[0074] Prescription: Poria 6000g, Arctium 1800g, Hedyotis diffusa 800g, Banzhilian 1000g, Achyranthes bidentata 2000g, atorvastatin calcium 1g.
[0075] Preparation Process:
[0076] 1) Weigh Hedyotis diffusa, Scutellaria barbata, Poria cocos, Arctium, Achyranthes bidentata according to the above prescription, dry and crush them through an 80-mesh sieve, add 8 times the amount of ethanol to reflux and extract 3 times, each time for 2 hours, combine the extracts, filter After that, the ethanol was recovered under reduced pressure and concentrated to a thick paste, and dried in vacuo to obtain the ethanol extract;
[0077] 2) Take the dregs after alcohol extraction in step 1, add 8 times the amount of water to decoct 3 times, 2 hours each time, combine the decoction, concentrate the filtrate under reduced pressure to a relative density of 1.15-1.20, and vacuum dry to obtain the water extract;...
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