Traditional Chinese medicine composition for curing chronic ulcerative colitis and preparation method thereof

A chronic ulcer and composition technology, applied in the field of traditional Chinese medicine, can solve the problems of increasing adverse reactions, easy recurrence, and reducing the quality of life of patients, and achieve the effects of no toxic side effects and side effects, no drug resistance, and quick effect.

Inactive Publication Date: 2013-04-17
QINGDAO HENGBO INSTR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Other immunomodulators are not routinely used because of their toxic and side effects. Therefore, Western medicine can relieve symptoms quickly in the initial stage of the disease, and the clinical remission rate is high. Phenomenon, reducing the quality of life of patients, the curative effect is not ideal

Method used

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preparation example Construction

[0071] The present invention also provides a preparation method of the above-mentioned traditional Chinese medicine composition, specifically:

[0072] Step 1: Pulverize Pulsatilla chinensis, Gentian, Folium Folium, Baiji, Sanbaicao, Senecio, and Banbangui, mix them in proportion to obtain a mixture, and add ethanol with an alcohol concentration of 70% to 80% to evenly moisten it , the mass ratio of the mixture to ethanol is 1:1~1:2, put it in a closed place for 12h~18h, put it into the percolation tank, and continue to add ethanol with an alcohol concentration of 70%~80% relative to the mass of the mixture 2~4 times, Continue immersion for 6h~12h, percolation, the flow rate is 5~7ml per minute, collect the percolation liquid, filter, and the filtrate is concentrated under reduced pressure to a relative density of 65°C under the condition of pressure of -0.06~-0.04MPa and temperature of 65°C 1.15~1.20 extract;

[0073] The second step is to adsorb the macroporous resin on the...

Embodiment 1

[0088] The concrete preparation of embodiment 1 granule 1

[0089] Grind 56g of Pulsatillae Radix, 40g of Gentiana, 77g of Folium Isatidis, 35g of Baiji, 46g of Sanbaicao, 27g of Senecio, and 32g of Scutellaria chinensis, and mix to obtain a mixture. Add 350g of ethanol with an alcohol concentration of 80% to evenly moisten it. Put it airtightly for 15 hours, put it into the percolation tank, continue to add 900g of ethanol with an alcohol concentration of 80%, continue to soak for 12 hours, percolate, the flow rate is 6ml per minute, collect the percolation liquid, filter, and the filtrate is at a pressure of -0.06MPa, At a temperature of 65°C, concentrate under reduced pressure to obtain an extract with a relative density of 1.20 at 65°C, and absorb the D101 macroporous resin on the extract. The mass ratio of the extract to the macroporous adsorption resin is 1:1. Elute with 0.4 times of water relative to the quality of the macroporous adsorption resin, then elute with 70% e...

Embodiment 2

[0090] The concrete preparation of embodiment 2 granules 2

[0091] Grind 53g of Pulsatilla pulsatillae, 37g of Gentiana, 74g of Folium Isatidis, 32g of Baiji, 43g of Sanbaicao, 24g of Senecio, and 29g of Selena, and mix them to obtain a mixture. Add 300g of ethanol with an alcohol concentration of 80% to evenly moisten it. Put it airtightly for 15 hours, put it into the percolation tank, continue to add 900g of ethanol with an alcohol concentration of 80%, continue to soak for 12 hours, percolate, the flow rate is 6ml per minute, collect the percolation liquid, filter, and the filtrate is at a pressure of -0.06MPa, At a temperature of 65°C, concentrate under reduced pressure to obtain an extract with a relative density of 1.20 at 65°C, and absorb the D101 macroporous resin on the extract. The mass ratio of the extract to the macroporous adsorption resin is 1:1. Elute with 0.4 times of water relative to the quality of the macroporous adsorption resin, then elute with 75% ethan...

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Abstract

The invention provides a traditional Chinese medicine composition for curing chronic ulcerative colitis. Bulk drugs of the traditional Chinese medicine composition include prepared rehmannia roots, vine of multiflower knotweed, myrrh, Chinese yam, rhizoma polygonati, myrobalan, asarum, rheum officinale, roots of Chinese pulsatilla, radix gentianae, folium isatidis, zedoary, roots of common vladimiria, fructus viticis, roots of red-rooted salvia, grifola, rhizoma bletillae, gallnut, pinellia ternate, alpinia oxyphylla, wadalee-gum-tree, saururus chinensis, groundsel, birthwort and perfoliote knotweed herb. The invention has the advantages that the traditional Chinese medicine composition has excellent curative effect, is quick to be effective, has low possibility of recurrence, has no toxic and side effect or side reaction, and has no drug resistance.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating chronic ulcerative colitis and a preparation method thereof. Background technique [0002] Chronic ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease of unknown etiology, characterized by chronic inflammation and ulcerative changes of the intestinal mucosa, the clinical lesions of the disease are located in the large intestine, showing continuous diffuse The distribution is characterized by chronic inflammation and ulceration of the colonic mucosa, and there are often obvious microcirculation disturbances in the local area. Clinically, it is characterized by symptoms such as diarrhea, mucus pus and blood, abdominal pain, and tenesmus. Due to repeated attacks, the mucosa is constantly destroyed and repaired, resulting in normal structure damage, colon deformation and shortening, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P1/04A61K35/64
Inventor 不公告发明人
Owner QINGDAO HENGBO INSTR
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