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Compound capsaicin preparation and applications thereof

A technology of capsaicin and compound recipes, applied in the field of medicine, can solve problems such as adverse reactions of hirsutism, and achieve significant hair growth and hair growth-promoting effects

Inactive Publication Date: 2013-05-01
URUMQI GENERAL HOSPITAL LANZHOU MILITARY AREA CHINESE P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sufficient clinical trials have confirmed that minoxidil has a good effect on male pattern hair loss and alopecia areata, but lo

Method used

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  • Compound capsaicin preparation and applications thereof
  • Compound capsaicin preparation and applications thereof
  • Compound capsaicin preparation and applications thereof

Examples

Experimental program
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preparation example Construction

[0027] The preparation method of compound capsaicin preparation of the present invention may further comprise the steps:

[0028] The capsaicin with a weight ratio of 0.03-0.075% is dissolved in a small amount of ethanol, added into the matrix, and stirred evenly to obtain the compound capsaicin preparation.

[0029] The matrix was prepared as follows:

[0030] Add the water phase components into the oil phase components, and stir while adding to obtain the matrix of the compound capsaicin preparation, wherein the water phase components include triethanolamine and an appropriate amount of distilled water in a weight ratio of 4 to 6%; the oil phase components include the following: Components in weight ratio: 25-30% of stearic acid, 4-5.2% of lanolin, 25-30% of liquid paraffin, 10-15% of glycerin, and 2-5% of stearyl alcohol.

[0031] Preferably, after the dissolved capsaicin is added into the matrix and stirred evenly, 0.1% by weight of racemic anisodamine is further added. ...

Embodiment 1

[0033] The preparation of embodiment 1 compound capsaicin preparation

[0034] Oil phase components: stearic acid 25-30%, lanolin 4-5.2%, liquid paraffin 25-30%, glycerin 10-15%, stearyl alcohol 2-5%;

[0035] Water phase composition: 4-6% triethanolamine, appropriate amount of distilled water;

[0036] Preparation method: slowly add the water phase ingredients to the oil phase ingredients, stir while adding, take capsaicin with a weight ratio of 0.03-0.075% and dissolve it with a small amount of ethanol, gradually add it to the matrix, stir evenly, add 0.1% of racemic Anisodamine (654-2), stir evenly to obtain compound capsaicin ointment preparation.

Embodiment 2

[0037] Embodiment 2 compound capsaicin preparation promotes hair growth experiment

[0038] The present invention uses the compound capsaicin preparation to carry out the pathological observation experiment of promoting hair growth in 45 C57 BL / 6 mice, and the result proves that the compound capsaicin preparation has obvious hair growth promoting effect.

[0039] 1. Preparation of depilatory animal model and treatment experiment of compound capsaicin preparation

[0040] Take 54 inbred C57 BL / 6 mice, male or female. Melt it with rosin / paraffin wax mixture (1:1), apply it on the back of the mouse, remove it after solidification and hardening, clean the back of the mouse with no injury and no hair root, and the depilated area is about 2cm×2cm, causing C57 BL / 6 mouse hair loss animal model.

[0041] Begin treatment on the 2nd day of depilatory model preparation, 45 mice are divided into blank control group at random, 2% minoxidil group, compound capsaicin preparation of the pre...

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Abstract

The present invention discloses a compound capsaicin preparation, which comprises 0.03-0.075% by weight of capsaicin and a matrix. The present invention further discloses a preparation method and applications of the compound capsaicin preparation. The compound capsaicin preparation has a significant hair growth promotion effect, and can be adopted as an alopecia treatment drug.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a compound capsaicin preparation and its application. Background technique [0002] Capsaicin is an alkaloid containing phenolic hydroxyl group, also known as capsaicin, its chemical name is: N-vanillyl-8-methyl-6-nonenamide, and its molecular formula is C 18 h 27 NO 3 , the structural formula is as follows, [0003] [0004] As a natural plant alkaloid, capsaicin is mainly used for analgesia and antipruritic. Its analgesic effect is equal to that of morphine, but its effect is longer than that of morphine, and it is not addictive. Capsaicin plays an analgesic and anaerobic role mainly by affecting the release, synthesis and storage of neuropeptide P substance. Capsaicin also has anti-inflammatory and antibacterial effects. Therefore, the medicinal value of capsaicin is very high. [0005] At present, the permanent hair loss caused by hair follicle damage, that is, the ...

Claims

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Application Information

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IPC IPC(8): A61K31/165A61K31/46A61P17/14
Inventor 刘璟曾平修彬华尹东锋周军
Owner URUMQI GENERAL HOSPITAL LANZHOU MILITARY AREA CHINESE P L A
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