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Polysaccharide sulfate dispersible tablet
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A technology of sodium alginate diester and dispersible tablets, which is applied in the field of dispersible tablets and can solve the problems of low bioavailability and slow onset of action
Active Publication Date: 2014-04-16
CP PHARMA QINGDAO CO LTD
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[0006] In order to solve the shortcomings of the existing sodium alginate diester preparations, such as slow onset of action and low bioavailability, the present invention has invented a sodium alginate diester inclusion compound dispersible tablet
Method used
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[0022] The prescription for dispersible tablets is (by weight):
[0023]
[0024]
[0025] Preparation:
[0026] 1. Prepare sodium alginate diester inclusion compound according to the following method:
[0027] (1) In water or aqueous ethanol medium, react sodium alginate diester with hydroxypropyl β-cyclodextrin in a certain proportion, filter the resulting solution through a microporous membrane until it is clear, and separate the package from the mixture. compounds; or
[0028] (2) In solid form, react sodium alginate diester with hydroxypropyl β-cyclodextrin; or
[0029] (3) Sodium alginate diester reacts with hydroxypropyl β-cyclodextrin for high-energy grinding.
[0030] 2. Mix the prescription amount of low-substituted hydroxypropyl cellulose, sorbitol, sodium cyclamate and alginate diester sodium inclusion compound according to the equal addit...
[0038] The prescription for dispersible tablets is (by weight):
[0039]
[0040] The preparation method is the same as above
[0041] Control group 1
[0042] The prescription for dispersible tablets is (by weight):
[0043]
[0044] The preparation method is the same as above
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Abstract
The application relates to a vitamin C clathrate compound dispersible tablet. Firstly, vitamin C is prepared into clathrate compound, and is then prepared into the dispersible tablet.
Description
technical field [0001] The present application relates to a dispersible tablet, specifically, a dispersible tablet of sodium alginate diester inclusion compound. Background technique [0002] Propyleneglycolalginatesodiumsulfate (PSS) is China's first marine sugar drug developed by Ocean University of my country. Prevention and treatment. PSS has been used clinically for more than 20 years, mainly for ischemic cerebrovascular diseases such as cerebral thrombosis, cerebral embolism, transient ischemic attack and cardiovascular diseases such as hypertension, hyperlipoproteinemia, coronary heart disease, Prevention and treatment of diseases such as angina pectoris. The total effective rate of PSS in the treatment of cardiovascular and cerebrovascular diseases is 80%~95%. With the clinical use and research, it has also been found that PSS has good curative effect on other diseases, such as cancer, diabetes, chronic kidney disease. glomerulonephritis, hepatitis, [0003] Psori...
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Application Information
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