Preparation method of nanometer strontium hydroxyapatite and application thereof

A strontium hydroxyapatite, nanotechnology, applied in nanotechnology, chemical instruments and methods, phosphorus compounds, etc., can solve problems such as material degradation rate decline, and achieve the effect of biodegradability assurance

Inactive Publication Date: 2014-12-10
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] At present, there are some reports on nano-strontium hydroxyapatite, such as the patents with patent numbers 200910056701.6 and 200410026586.5, respectively. The prepared products are only solid solutions of nano-hydroxyapatite and nano-strontium hydroxyapatite. The process of high temperature is also adopted in the method, which causes the degradation rate of the material in the organism to decrease.

Method used

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  • Preparation method of nanometer strontium hydroxyapatite and application thereof
  • Preparation method of nanometer strontium hydroxyapatite and application thereof
  • Preparation method of nanometer strontium hydroxyapatite and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The first step: use deionized water to prepare respectively 50 ml of strontium nitrate aqueous solution and 0.03 mol / L diammonium hydrogen phosphate aqueous solution with a concentration of 0.05 mol / L in a volumetric flask;

[0027] The second step: transfer the strontium nitrate aqueous solution to a flask, add dropwise an ammonia solution with a concentration of 25% by mass in the strontium nitrate aqueous solution, and adjust the pH value of the strontium nitrate aqueous solution to 10-10.5;

[0028] The third step: placing the strontium nitrate aqueous solution in a water bath at 1-25°C, slowly adding the diammonium hydrogen phosphate aqueous solution dropwise into the strontium nitrate aqueous solution, and at the same time slowly adding ammonia water with a concentration of 0.1-2.0mol / L, and Stir continuously to keep the pH value of the reaction system at 10 to 10.5. After the diammonium hydrogen phosphate aqueous solution is added dropwise, a suspension containing...

Embodiment 2

[0032] The first step: use deionized water to prepare respectively 50 ml of strontium nitrate aqueous solution and 0.06 mol / L diammonium hydrogen phosphate aqueous solution with a concentration of 0.1 mol / L in a volumetric flask;

[0033] The second step: transfer the strontium nitrate aqueous solution to a flask, add dropwise an ammonia solution with a concentration of 25% by mass in the strontium nitrate aqueous solution, and adjust the pH value of the strontium nitrate aqueous solution to 10-10.5;

[0034] Step 3: Put the strontium nitrate aqueous solution in a water bath at 1-25°C, slowly add the diammonium hydrogen phosphate aqueous solution dropwise into the strontium nitrate aqueous solution, and at the same time slowly add Ammonia water, and constantly stirring, keep the pH value of the reaction system at 10-10.5, after the diammonium hydrogen phosphate aqueous solution is added dropwise, a suspension containing nano-strontium hydroxyapatite is obtained; continue to sti...

Embodiment 3

[0037] The first step: use deionized water to prepare 50ml of 0.5mol / L strontium nitrate aqueous solution and 50ml of 0.3mol / L diammonium hydrogen phosphate aqueous solution in a volumetric flask, and the rest of the steps are the same as in Example 1 or Example 2.

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Abstract

The invention discloses a preparation method of nanometer strontium hydroxyapatite, which comprises the following steps: preparing a strontium nitrate aqueous solution and a diammonium phosphate aqueous solution with certain concentrations, adjusting the pH value of the strontium nitrate aqueous solution, mixing the strontium nitrate and the diammonium phosphate aqueous solutions to generate a nanometer strontium hydroxyapatite precipitate, standing and aging, filtering to remove the upper supernatant, washing and filtering the nanometer strontium hydroxyapatite precipitate to be neutral, performing centrifugal dewatering and freeze drying to finally obtain the nanometer strontium hydroxyapatite. When compared with nanometer hydroxyapatite, the nanometer strontium hydroxyapatite obtained in the preparation method has better biodegradability and better osteoinductivity; meanwhile, the preparation process avoids high temperature process, so the biodegradability is further ensured; The nanometer strontium hydroxyapatite obtained in the preparation method has good prospects in the application of bone repair materials.

Description

technical field [0001] The invention relates to a preparation method and application of nano strontium hydroxyapatite. Background technique [0002] Hydroxyapatite is the main component in human bones, and its chemical formula is Ca 10 (PO 4 ) 6 (OH) 2 , and its calcium-phosphorus ratio is 1.67. The hydroxyapatite in human bone tissue is mainly nano-scale needle-like single-crystal hydroxyapatite. The diameter of the needle-like single-crystal hydroxyapatite is in the range of nanometers, and it is distributed in the collagen network along a certain orientation. . Therefore, the nano-hydroxyapatite material is very similar to the tissue composition in the human body, and is also being used more and more widely. Nano-hydroxyapatite has better biological properties, which can effectively improve the shortcomings of traditional hydroxyapatite materials such as long-term non-degradation, poor physical and mechanical properties, high brittleness, and weak osteoinductive eff...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/32B82Y40/00A61L27/12A61L27/50
Inventor 郝永强朱邦尚晏焕青
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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