Preparation method of nanometer strontium hydroxyapatite and application thereof

A strontium hydroxyapatite, nanotechnology, applied in nanotechnology, chemical instruments and methods, phosphorus compounds, etc., can solve problems such as material degradation rate decline, and achieve the effect of biodegradability assurance
CN103086337BInactive Publication Date: 2014-12-10SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
Publication Date
2014-12-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a preparation method of nanometer strontium hydroxyapatite, which comprises the following steps: preparing a strontium nitrate aqueous solution and a diammonium phosphate aqueous solution with certain concentrations, adjusting the pH value of the strontium nitrate aqueous solution, mixing the strontium nitrate and the diammonium phosphate aqueous solutions to generate a nanometer strontium hydroxyapatite precipitate, standing and aging, filtering to remove the upper supernatant, washing and filtering the nanometer strontium hydroxyapatite precipitate to be neutral, performing centrifugal dewatering and freeze drying to finally obtain the nanometer strontium hydroxyapatite. When compared with nanometer hydroxyapatite, the nanometer strontium hydroxyapatite obtained in the preparation method has better biodegradability and better osteoinductivity; meanwhile, the preparation process avoids high temperature process, so the biodegradability is further ensured; The nanometer strontium hydroxyapatite obtained in the preparation method has good prospects in the application of bone repair materials.
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Description

technical field

[0001] The invention relates to a preparation method and application of nano strontium hydroxyapatite. Background technique

[0002] Hydroxyapatite is the main component in human bones, and its chemical formula is Ca 10 (PO 4 ) 6 (OH) 2 , and its calcium-phosphorus ratio is 1.67. The hydroxyapatite in human bone tissue is mainly nano-scale needle-like single-crystal hydroxyapatite. The diameter of the needle-like single-crystal hydroxyapatite is in the range of nanometers, and it is distributed in the collagen network along a certain orientation. . Therefore, the nano-hydroxyapatite material is very similar to the tissue composition in the human body, and is also being used more and more widely. Nano-hydroxyapatite has better biological properties, which can effectively improve the shortcomings of traditional hydroxyapatite materials such as long-term non-degradation, poor physical and mechanical properties, high brittleness, and weak osteoinductive eff...

Claims

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