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Quality control method of loins-strengthening and kidney-invigorating medicine

A quality control method, a strong waist and healthy technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of lack of specificity, chemical identification of constituent drugs, and quantitative determination of main drugs, etc., to achieve strong specificity , good reproducibility and easy operation

Active Publication Date: 2013-06-12
山西振东五和堂制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The above-mentioned quality standards have relatively serious defects: first, the standard does not carry out quantitative determination of the active ingredient content of the main drug; second, more than 50% of the constituent drugs have not been chemically identified, and the existing identification is to use a common color reagent Identify a large category, lack of specificity

Method used

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  • Quality control method of loins-strengthening and kidney-invigorating medicine
  • Quality control method of loins-strengthening and kidney-invigorating medicine
  • Quality control method of loins-strengthening and kidney-invigorating medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: TLC identification of cattle Dali and dog ridges.

[0026] Take 6g of Zhuangyao Jianshen Pill, add 3g of diatomaceous earth, grind well, put it in a stoppered Erlenmeyer flask, add 10ml of water to moisten it, add 50ml of ethyl acetate, ultrasonicate for 30 minutes, filter, recover the solvent to dryness, Add 1ml of methanol to the residue to dissolve it as the test solution. In addition, 2 g of Niu Dali's reference medicinal materials and 2 g of Gouji's reference medicinal materials were taken, and the reference medicinal material solution was prepared in the same way. According to the test of thin-layer chromatography (Appendix VI B of "Chinese Pharmacopoeia" 2005 edition), draw 6 μl of each of the above three solutions, respectively spot on the same silica gel G thin-layer plate, and mix with toluene-acetone-formic acid (5:1: 0.2) as developing agent, unfold, take out and dry. View under UV light (365nm). In the chromatogram of the test product, fluores...

Embodiment 2

[0027] Embodiment 2: TLC identification of black tiger.

[0028] Get 2 g of the black tiger reference medicinal material, and prepare the reference medicinal material solution according to the preparation method of the test solution in Example 1. According to the thin-layer chromatography (Appendix VI B of "Chinese Pharmacopoeia" 2005 edition), draw 15 μl of the test solution of Example 1 and 8 μl of the reference medicinal material solution, respectively spot on the same silica gel G thin-layer plate, add chloroform -Ethyl acetate-toluene-formic acid (5:6:3:1) as the developer, develop, take out, dry, spray with 10% sulfuric acid ethanol solution, heat at 105°C until the color of the spots is clear, put in a UV lamp (365nm) to view. In the chromatogram of the test product, at the position corresponding to the chromatogram of the control medicinal material, there are fluorescent spots of the same color.

Embodiment 3

[0029] Example 3: TLC identification of Spatholobus Spatholobus.

[0030] Get 2 g of the control medicinal material of Spatholobus Spatholobus, and prepare the control medicinal material solution according to the preparation method of the test solution in Example 1. According to the thin-layer chromatography ("Chinese Pharmacopoeia" 2005 edition, an appendix VI B) test, absorb 6 μl of the test solution of Example 1 and the above-mentioned control medicinal material solution, respectively spot on the same silica gel G thin-layer plate, and use toluene ( water saturated) - ethyl formate - formic acid (5:4:0.8) as the developing agent, develop, take out, dry in the air, spray with 10% sulfuric acid ethanol solution, heat at 105°C until the spots are clear in color, put in a UV lamp ( 365nm). In the chromatogram of the test product, at the position corresponding to the chromatogram of the control medicinal material, there are fluorescent spots of the same color.

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Abstract

The invention discloses a quality control method of a loins-strengthening and kidney-invigorating medicine. In the method, beautiful millettia root, rhizoma cibotii, kadsura coccinea, caulis spatholobi, parasitic loranthus and glossy privet fruit in the medicine are respectively identified by a thin layer chromatography; and the content of protocatechuic acid and the content of protocatechuic aldehyde in the medicine are measured via a liquid chromatography. In the quality control method established by the invention, the medicine material identifying method is mature and feasible, strong in specificity, negative and interference-free; the content measurement method is easy in operation, high in precision and good in reproducibility; and by adopting the quality control method disclosed by the invention, the quality of the medicine can be precisely and stably controlled to adapt to the industrial and stable production of the medicine.

Description

technical field [0001] The invention relates to a traditional Chinese medicine for strengthening the waist and invigorating the kidney, in particular to a quality control method of the medicine. Background technique [0002] Zhuangyao Jianshen Pill is a drug for deficiency syndromes, used for kidney deficiency, low back pain, weak knees, frequent urination, nocturnal emission, rheumatic bone pain, and neurasthenia. [0003] Zhuangyao Jianshen Pills are currently included in the third volume of the Ministry of Health's Drug Standards for Traditional Chinese Medicine Prescriptions. The following are specified in this quality standard. [0004] 1) Take this product and observe it under a microscope: the mosaic crystal is microscopically colorless, with a diameter of about 45um and a thick wall. The diameter of the square crystal of calcium oxalate is about 3um, and many are mosaic on the microscopic surface. Crystal-containing thick-walled cells are colorless or light yellow,...

Claims

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Application Information

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IPC IPC(8): G01N30/90G01N30/02
Inventor 王六贵吕建英
Owner 山西振东五和堂制药有限公司
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