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External medicament for treating leucoderma and preparation method thereof

A topical medicine and vitiligo technology, applied in the field of topical medicines for the treatment of vitiligo, can solve problems such as high price, folliculitis, local irritation, etc., and achieve the effect of low incidence of adverse reactions

Inactive Publication Date: 2013-06-26
THE AFFILIATED HOSPITAL OF SHANDONG UNIV OF TCM +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, some scholars have used it to treat vitiligo, etc., but it is expensive and often has side effects such as local irritation and folliculitis.

Method used

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  • External medicament for treating leucoderma and preparation method thereof
  • External medicament for treating leucoderma and preparation method thereof
  • External medicament for treating leucoderma and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0178] The preparation method of the external medicine for treating vitiligo adopts the following steps:

[0179] a. Soak 15 kg of Tribulus terrestris, 35 kg of Polygonum multiflorum (manufactured), 10 kg of psoralen, 15 kg of Angelica dahurica, 5 kg of fig leaves, and 20 kg of licorice (raw) in absolute ethanol, soak at room temperature for 42 days, discard slag, to obtain the extract;

[0180] b. Concentrating the extract solution of step a to 55% of the volume of the extract solution, reclaiming ethanol to obtain a concentrated solution;

[0181]C, according to glycerol: stearic acid: sodium hydroxide: laurocapram: water=85:75:2:3:330 weight ratio makes matrix;

[0182] d. Mix the concentrated solution of step b with the matrix of step c according to the ratio of concentrated solution: matrix = 1 kg: 4.5 kg to make a cream.

Embodiment 2

[0184] The preparation method of the external medicine for treating vitiligo adopts the following steps:

[0185] a. Soak 60 kg of Tribulus terrestris, 15 kg of Polygonum multiflorum (manufactured), 20 kg of psoralen, 5 kg of Angelica dahurica, 10 kg of fig leaves, and 10 kg of licorice (raw) in absolute ethanol, soak at room temperature for 56 days, discard slag, to obtain the extract;

[0186] b. Concentrating the extract in step a to 45% of the volume of the extract, reclaiming ethanol to obtain a concentrate;

[0187] C, according to glycerol: stearic acid: sodium hydroxide: laurocapram: water=95:65:3:2:340 weight ratio makes matrix;

[0188] d. Mix the concentrated solution of step b with the base of step c according to the ratio of concentrated solution: base = 1 kg: 5.5 kg to make a cream.

Embodiment 3

[0190] The preparation method of the external medicine for treating vitiligo adopts the following steps:

[0191] a. Soak 40 kg of Tribulus terrestris, 25 kg of Polygonum multiflorum (manufactured), 15 kg of psoralen, 10 kg of Angelica dahurica, 7 kg of fig leaves, and 15 kg of licorice (raw) in absolute ethanol, soak at room temperature for 50 days, discard slag, to obtain the extract;

[0192] b. Concentrating the extract in step a to 50% of the volume of the extract, reclaiming ethanol to obtain a concentrate;

[0193] C, according to glycerol: stearic acid: sodium hydroxide: laurocapram: water=90:70:2.2:2.5:335 weight ratio makes matrix;

[0194] d. Mix the concentrated solution of step b with the matrix of step c according to the ratio of concentrated solution: matrix = 1 kg: 5.0 kg to make a cream.

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Abstract

The invention provides an external medicament for treating leucoderma and a preparation method thereof. Chinese herbal medicine raw materials for preparing active ingredients consist of the following components in parts by weight: 15-60 parts of tribulus terrestris, 15-35 parts of polygonum multiflorum (prepared), 10-20 parts of fructus psoraleae, 5-15 parts of dahurian angelica root, 5-10 parts of fig leaves and 10-20 parts of (raw) licorice. The preparation method, according to the specified amount of every component, comprises the following steps of: a, soaking the tribulus terrestris, polygonum multiflorum (prepared), fructus psoraleae, dahurian angelica root, fig leaves and (raw) licorice into absolute ethyl alcohol for 6-8 weeks at room temperature, and removing residues to obtain a leaching solution; b, concentrating the leaching solution obtained in the step a until the volume of the leaching solution is reduced by 45-55%, and recovering ethanol to obtain a concentrated solution; and c, adding the concentrated solution obtained in the step b into a base material to prepare a cream.

Description

Technical field: [0001] The invention relates to medicines, more specifically to a medicine for external use for treating vitiligo; in addition, it also relates to a preparation method of the medicine for external use. Background technique: [0002] Vitiligo is a common pigmentary disorder skin disease, which is characterized by partial or generalized depigmentation and the formation of white spots, which is called "white bark wind" and "Vitiligo" in traditional Chinese medicine. The disease is easy to diagnose and difficult to treat, and it is an intractable and persistent disease in dermatology, which brings great suffering to patients. Therefore, vitiligo has always been one of the key subjects of dermatology research. [0003] Western medicine believes that the incidence of vitiligo is related to various factors such as autoimmune dysfunction, abnormal mental and neurochemical functions, heredity and trace element deficiency. Traditional Chinese medicine believes that t...

Claims

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Application Information

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IPC IPC(8): A61K36/704A61K9/06A61P17/00
Inventor 宋业强陈会苓唐志坤赵颖董雅琴韩王臣赟许力文
Owner THE AFFILIATED HOSPITAL OF SHANDONG UNIV OF TCM
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