Related serum microribonucleic acid marker for human severe preeclampsia and application of marker

Abstract

The invention belongs to the fields of genetic engineering and clinical medicine, and discloses a related serum microribonucleic acid marker for human severe preeclampsia and application of the marker. The marker is selected from more of hsa-miR-193a-5p, hsa-miR-424 and hsa-miR-10a. The marker has the specificity and sensitivity on a sufferer with severe preeclampsia, and can be used for preparing a diagnosis or monitoring kit for severe preeclampsia.

Description

field of invention

[0001] The invention belongs to the fields of genetic engineering and clinical medicine, and relates to serum microRNA (miRNA) markers related to the occurrence of human severe preeclampsia and applications thereof. Background technique

[0002] The incidence rate of hypertensive disorders during pregnancy in my country is about 9.4%, and it is 7% to 12% in foreign reports. It is an important cause of maternal and perinatal deaths. Hypertensive disorders of pregnancy include gestational hypertension, preeclampsia, eclampsia, chronic hypertension with preeclampsia, and chronic hypertension. Preeclampsia (PE) is a multisystem disease unique to pregnancy, with an incidence rate of 1% to 5%. The main clinical features are hypertension, proteinuria, and edema after 20 weeks of pregnancy. Preeclampsia is divided into mild and severe according to the severity of the disease. Mild preeclampsia refers to blood pressure ≥ 140 / 90mmHg, urine protein (+) or urine pro...

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