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Measuring method of powder filling in capsules

A measurement method and technology of medicinal powder, applied in the direction of volume measurement instrument/method, measurement device, measurement capacity, etc., can solve the problems of limited monitoring of capsule particle weight, difficult maintenance, cumbersome operation, etc., and achieve rapid completion of the measurement process and benefit The effect of popularizing and using the method is simple and easy

Active Publication Date: 2016-01-13
韩杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The weighing process of various mechanical balances and electronic balances requires manual operation. The disadvantages are: slow detection speed, low efficiency, and cumbersome operation; online automatic weighing cannot be realized, and it can only be used for random inspection, and it is impossible to realize capsule-by-capsule Weighing, this method is extremely limited in monitoring the capsule grain weight, and there are still many capsules whose grain weight does not meet the requirements cannot be detected
Although various devices using the principle of weight sensors have greatly improved their work efficiency and can weigh capsules one by one, they also have significant disadvantages: the equipment is precise and expensive, which is not conducive to promotion in pharmaceutical companies; the system is complex and difficult to maintain. , high maintenance cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Choose a container whose volume can be changed, such as a container with at least part of the wall being elastic, or a cylinder, etc. Put the capsule to be tested into the container, seal the container, and keep the volume of the container at the initial value V1 by means of a support plate or a fixed frame.

[0016] Inject compressed air into the container to make the air pressure in the container rise gradually, and the compressed air will enter the capsule through the gap on the capsule shell, so the air pressure inside the capsule will also gradually rise until the air pressure in the container reaches P1, and stop inflating .

[0017] Remove the means applied to the container to maintain its container, the container will automatically expand until the internal air pressure drops to be equal to the external air pressure, that is, P2, at this time, the volume of the container will increase to V2.

[0018] According to Boyle's law: P1(V1-V0-V)=P2(V2-V0-V), wherein, V...

Embodiment 2

[0021] Similar to Embodiment 1, first select a container with a variable volume, put the capsule to be tested into the container, seal the container, and keep the volume of the container at the initial value V1 by means of a support plate or a fixed frame.

[0022] Vacuumize the container, so that the air pressure in the container drops to P1. During this process, the air inside the capsule will leak out from the gap on the capsule shell, so that the air pressure inside the capsule also drops to P1, and the vacuuming is stopped. operate.

[0023] Cancel the means of maintaining the volume of the container such as the support plate or the fixed frame, so that the container automatically shrinks under the action of the internal and external pressure difference until the internal and external air pressure is balanced, that is, the air pressure in the container is equal to the external air pressure P2, and the volume of the container is reduced to V2.

[0024] Same as Embodiment 1...

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PUM

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Abstract

The invention relates to a method for measuring the capsule powder packing volume. A capsule is put in a sealed container with the changeable volume, air pressure of the container is changed by charging compressed air or vacuumizing under the premise that the volume of the container is not changed, then the container changes the volume automatically under the effect of inside-outside air pressure difference, and the volume of the powder in the capsule is measured according to volume change. The method is simple and easy to implement and low in implementation cost.

Description

technical field [0001] The invention relates to a measuring method for determining the volume of a non-gas substance, in particular to a method for measuring the content of medicine powder filled in a capsule. Background technique [0002] In the field of pharmaceutical industry, due to the influence of various factors such as the stability of the capsule filling equipment itself and the characteristics of the medicinal powder itself, the weight of the medicinal powder contained in the capsule, that is, the capsule grain weight, fluctuates during the production process of the capsule. As far as drugs for diseases are concerned, the amount of drug contained in a unit dose, that is, the grain weight of each capsule must be stabilized within a narrow range, so pharmaceutical companies will strictly control and measure the grain weight of capsules, and test And remove the defective products whose grain weight does not meet the requirements. [0003] The current method of measur...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01F22/02
Inventor 韩杰
Owner 韩杰
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