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Application of viola diffusa in preparation of medicine for treating viral hepatitis

A technology for viral hepatitis and Viola, applied in antiviral agents, drug combinations, pharmaceutical formulations, etc., can solve problems such as drug resistance, rebound, and limited therapeutic effects

Inactive Publication Date: 2014-08-27
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment of HBV infection is mostly based on interferon and nucleoside drugs. Interferon can inhibit virus replication, but it is difficult to clear the virus. It is not recommended for patients with severe hepatitis and other patients with few liver cells; nucleoside drugs can inhibit HBV -DNA reverse transcriptase activity, but it is easy to develop drug resistance, and "rebound" phenomenon is easy to occur after drug withdrawal, and the therapeutic effect is very limited

Method used

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  • Application of viola diffusa in preparation of medicine for treating viral hepatitis

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0037] Take 1kg of dried Viola vine whole herb, soak in 10L of water for 30 minutes, decoct for 2 hours, filter while hot, add 6L of water to the residue and cook for 1 hour, filter while hot, and combine the decoction. The decoction is concentrated to a thick extract with a specific gravity of 1.05 to 1.1, and dried to obtain the extract of the present invention.

example 2

[0039] Take 1kg of dried Viola vine whole herb, soak in 12L of water for 30 minutes, decoct for 1.5 hours, filter while hot, add 5L of water to the residue and cook for 1 hour, filter while hot, and combine the decoction. The decoction is concentrated to a thick extract with a specific gravity of 1.05 to 1.1, and dried to obtain the extract of the present invention.

example 3

[0041] Take 1 kg of dried Viola vine whole herb, add 8L of water to soak for 30 minutes, decoct for 2 hours, filter while hot, add 7L of water to the residue and cook for 2 hours, filter while hot, and combine the decoction. The decoction is concentrated to a thick extract with a specific gravity of 1.05 to 1.1, and dried to obtain the extract of the present invention.

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Abstract

The invention relates to a novel application of viola diffusa in preparation of a medicine, and in particular relates to an application of the viola diffusa in preparation of a medicine for treating the viral hepatitis. A viola diffusa extract has an obvious effect for inhibiting HBeAg and HBsAg which are secreted by a HepG2.2.15 cell strain and can be used for preparing the medicine for preventing and treating the viral hepatitis. The medicine for resisting hepatitis B viruses is a clinically acceptable solid or liquid oral administration preparation which is prepared by the viola diffusa extract and a conventional amount of medically acceptable auxiliary materials.

Description

technical field [0001] The invention relates to a pharmaceutical preparation containing an undetermined structure from a plant, in particular to a new application of a plant of the genus Viola of the Viola family in pharmacy. Background technique [0002] Viola diffusa Ging (Viola diffusa Ging) is an annual or perennial herbaceous plant of the genus Viola (Violaceae) in the family Violaceae. , common throughout Fujian. Violet is mostly grown on the side of the road in the field, in the open field or on the side of the road on the hillside, and is also found in the moist place of the sparse forest. The whole herb is used as medicine, which has the effects of clearing heat and detoxifying, dissipating blood stasis and reducing swelling, removing putrefaction and promoting muscle growth, clearing lung and relieving cough. Publishing House, published in 1990). Viola is slightly bitter and cool; it has the effect of clearing away heat and detoxifying; it is mainly used for hepa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/86A61P1/16A61P31/14A61P31/20
CPCY02A50/30
Inventor 朱全红戴娇娇
Owner SOUTHERN MEDICAL UNIVERSITY
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