Preparation of high drug loading multifunction nanometer drug with combination treatment effect

A technology with high drug loading and therapeutic effect, applied in the direction of drug combinations, inorganic non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of carrier biotoxicity, metabolism in the body, and low drug loading, and achieve Good repeatability, easy operation, simple and easy operation effect

Active Publication Date: 2013-08-21
SUZHOU UNIV
View PDF1 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existence of a large number of carriers will bring many serious problems, such as low drug loading, possible carrier biotoxicity and metabolism problems in the body, etc., which greatly limits its application.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation of high drug loading multifunction nanometer drug with combination treatment effect
  • Preparation of high drug loading multifunction nanometer drug with combination treatment effect
  • Preparation of high drug loading multifunction nanometer drug with combination treatment effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0030] The present invention will be described in detail below with reference to the accompanying drawings and in combination with embodiments.

[0031] The preparation of the multifunctional nanomedicine with combined therapeutic effect of high drug loading is characterized in that it comprises the following steps:

[0032] Step 1) Prepare hydrophobic organic anticancer drug molecules into precursor nanoparticle suspension by solvent exchange method; the specific method is to dissolve the organic anticancer drug molecules in a good solvent to prepare an organic anticancer drug molecule solution , taking an appropriate volume of the organic anticancer drug molecular solution and adding it to an appropriate amount of poor solvent, stirring magnetically for 5 minutes and then standing still to obtain a precursor nanoparticle suspension;

[0033] Step 2) Add an appropriate volume of 1 mg / mL cationic surfactant aqueous solution to the suspension of the precursor nanoparticles, and...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses preparation of a high drug loading multifunction nanometer drug with a combination treatment effect, wherein an oversaturation degree of a hydrophobic anti-cancer drug in water, a cation type surfactant concentration, and the amount of an added Au seed are controlled, and a chemical effect between a disulfide bond in a hydrophilic surfactant and the surface of a Au shell is adopted to carry out hydrophilic modification on the surface of a nanometer drug so as to achieve preparation of high drug loading multifunction nanometer drug with characteristics of chemotherapy and thermotherapy combination treatment effect and stable bioenvironment, wherein a layer of a Au shell grows on the nanometer drug. With the technical scheme, the preparation method is simple, experimental basis is provided for preparation of other multifunction nanometer materials for cancer treatments, and wide applications can be provided for the fields of biology, medicine, chemistry and the like.

Description

technical field [0001] The present invention relates to the preparation of hydrophobic organic anticancer drug nanoparticles, the growth of Au shells on the surface of the nanoparticles, and the hydrophilic modification of the surface of the Au shells to obtain a biological environment with a combined therapeutic effect of chemotherapy and thermotherapy with high drug loading Stable multifunctional nanomedicine, specifically, the present invention belongs to the preparation of multifunctional nanomedicine with combined therapeutic effect with high drug loading. Background technique [0002] Cancer has become one of the major diseases threatening human health. Effective treatment of cancer has become a top priority in scientific research. Chemotherapy is one of the indispensable and important methods in tumor treatment. However, due to the low water solubility, limited stability, rapid blood clearance and lack of selective entry into the body, most chemotherapeutic drugs cur...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K47/02A61K31/4745A61P35/00
Inventor 张秀娟李伟
Owner SUZHOU UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap