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Compound fructus forsythiae-radix bupleuri oil nanoemulsion and preparation method

A technology for Bupleurum oil and emulsion preparation, which is applied in the field of medicine, can solve the problems of low bioavailability, affect the therapeutic effect, poor stability, etc., and achieve the effects of improving solubility, simple method and process, and improved anti-corrosion performance.

Active Publication Date: 2014-12-24
张晓燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Forsythia oil and Bupleurum oil have good curative effect and small toxic and side effects, but they are insoluble in water, volatile, poor in stability, and low in bioavailability, thus affecting their therapeutic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Accurately weigh 28.0g of Tween-80, 28.0g of ethanol, and 8.0g of ethyl acetate, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 20°C, add 0.1g of forsythia oil, 0.1g of Oil, vitamin C 0.05g, vitamin B 1 Add 0.05g directly, stir thoroughly, then slowly add distilled water to it, and manually stir while adding distilled water. At the beginning, the viscosity of the system is small. When suddenly thinning, what produce now is the stable light yellow transparent forsythia bupleurum oil nanoemulsion oral liquid, claiming that its total weight is 100.0g.

Embodiment 2

[0036] Accurately weigh 12.0g of Tween-80, 15.0g of ethanol, and 3.0g of ethyl acetate, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 20°C. Oil, vitamin C 0.03g, vitamin B 1 Add 0.03g directly, stir thoroughly, then slowly add distilled water to it, and manually stir while adding distilled water. At the beginning, the viscosity of the system is small. When suddenly thinning, what produce now is the stable pale yellow transparent forsythia bupleurum oil nanoemulsion oral liquid, claiming that its total weight is 100.1g.

Embodiment 3

[0038] Accurately weigh 16.0g of Tween-80, 20.0g of ethanol, and 4.0g of ethyl acetate, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 20°C. Oil, vitamin C 0.02g, vitamin B 1 Add 0.02g directly, stir thoroughly, then slowly add distilled water to it, and manually stir while adding distilled water. At the beginning, the viscosity of the system is small. When suddenly thinning, what produce now is the stable light yellow transparent forsythia bupleurum oil nanoemulsion oral liquid, claiming that its total weight is 100.0g.

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PUM

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Abstract

A compound nanoemulsion of fructus forsythiae and radix bupleuri oil, having a droplet diameter of between 10 nm and 100 nm, and prepared from raw materials in the following percentage by weight: 12.00%-28.00% of a surfactant, 15.00%-30.00% of a cosurfactant, 3.00%-8.00% of oil, 0.10%-5.00% of fructus forsythiae oil, 0.10%-5.00% of radix bupleuri oil, 0.01%-0.05% of vitamin C, 0.01%-0.05% of vitamin B1, and 20.00%-68.40% of distilled water, the total percentage by weight of all the raw materials being 100%.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a compound forsythia-bupleurum oil nanoemulsion preparation, in particular to a transparent and stable compound forsythia-bupleurum oil nanoemulsion preparation. Background technique [0002] Forsythia is a traditional Chinese medicine for clearing heat and detoxifying. Forsythia has antibacterial, cardiotonic, diuretic, and antiemetic effects. The main components of the volatile oil of Forsythia are B-pinene, A-pinene and so on. Forsythia volatile oil has antibacterial and antiviral effects, and has obvious inhibitory effects on Staphylococcus aureus, Diplococcus pneumoniae and Candida albicans. Bupleurum oil is yellow-brown to brown volatile essential oil, disperses and reduces fever, raises yang and soothes the liver. For cold and fever, alternating cold and heat, malaria, stagnation of Qi due to depression of the liver, distending pain in the chest and hypochondriac. At present, the m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/634A61K9/107A61K47/10A61K47/34A61K47/14A61P31/00A61P11/00A61K31/375A61K31/51
CPCA61K47/14A61K31/375A61K31/51A61K36/634A61K36/233A61K9/1075A61P11/00A61P31/00A61K2300/00
Inventor 张晓燕
Owner 张晓燕
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