Brucellin live vaccine freezing-drying protecting agent for intradermal injection

A technology of freeze-drying protective agent and intradermal injection, which is applied in the direction of freeze-drying delivery, antibacterial drugs, bacterial antigen components, etc. It can solve the problems of vaccine allergy and other problems, and achieve the effect of reducing allergic reactions, good stability, and high efficacy

Active Publication Date: 2015-05-20
NAT INST FOR FOOD & DRUG CONTROL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The invention provides a gelatin-free lyoprotectant for Brucella live vaccine for intradermal injection, which solves the problem of vaccine allergy that may be caused by animal-derived gelatin components

Method used

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  • Brucellin live vaccine freezing-drying protecting agent for intradermal injection
  • Brucellin live vaccine freezing-drying protecting agent for intradermal injection
  • Brucellin live vaccine freezing-drying protecting agent for intradermal injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Weigh the following substances: lactose 10g, sodium glutamate 20g, thiourea 20g; dissolve the above substances in an appropriate amount of sterilized water for injection, dilute to 1L and adjust the pH value to 7.2 with sodium hydroxide solution; autoclave to obtain .

Embodiment 2

[0014] Weigh the following substances: lactose 50g, sodium glutamate 10g, thiourea 9g; dissolve the above substances in an appropriate amount of sterilized water for injection, dilute to 1L and adjust the pH value to 7.4 with sodium hydroxide solution; autoclave to obtain .

Embodiment 3

[0016] Weigh the following substances: 100g of lactose, 5g of sodium glutamate, and 5g of thiourea; dissolve the above substances in an appropriate amount of sterile water for injection, dilute to 1L and adjust the pH value to 7.5 with sodium hydroxide solution; filter and sterilize to obtain .

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Abstract

The invention discloses a vaccine freezing-drying protecting agent without animal origin gelatin components. The agent takes sterile injection water as a solvent, and each liter of the protecting agent contains 10-100g of lactose, 5-20g of sodium glutamate and 5-20g of thiourea. The vaccine freezing-drying protecting agent is applied to freezing-drying protection on brucellin live vaccines for intradermal injection.

Description

technical field [0001] The invention relates to a gelatin-free freeze-drying protectant for vaccines, which is used for freeze-drying protection of live Brucella vaccines for intradermal injection, and belongs to the technical field of vaccine production. Background technique [0002] In order to facilitate the transportation and storage of live bacterial vaccines, they are usually made into freeze-dried preparations. In order to ensure the live bacteria rate of the live bacterial vaccine during the freeze-drying process and during the transportation and storage process, the prior art generally uses a lyoprotectant during the preparation of the live bacterial vaccine. Currently domestic brucella vaccines are all freeze-dried live vaccines for scratches on the skin. There are many steps in the vaccination process, and the scratches are often of different depths, making it difficult to control the immune effect. In order to solve this problem, attempts have been made to prepa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/10A61K47/26A61K47/18A61K47/20A61K9/19A61P31/04
Inventor 魏东王国治
Owner NAT INST FOR FOOD & DRUG CONTROL
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