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A technology of albendazole ivermectin powder and albendazole, which is applied in the field of wettable albendazole ivermectin powder and its preparation, can solve problems such as inconvenient use, and achieve improved dispersibility and production The effect of low cost and convenient clinical drinking water administration
Inactive Publication Date: 2013-10-09
CHENGDU QIANKUN VETERINARY PHARMA +1
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[0004] The present invention aims at the disadvantages of inconvenient use of existing compound products of avermectins and albendazole, and provides a wettable albendazole that can be uniformly dispersed in water and administered by drinking water or spraying on feed Vermectin powder
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Embodiment 1
[0025] Example 1 Preparation of wettable albendazole and ivermectin powder of the present invention
[0026] Take 10g albendazole, 0.2g ivermectin, 2.5g magnesium stearate, 49.5g powdered sugar, 9g sodium lauryl sulfate, 2g xanthan gum, 0.9g fresh milk flavor, 0.9g sodium saccharin, 25 g of sodium citrate, the above-mentioned raw and auxiliary materials are uniformly mixed, crushed to 200 mesh ultra-fine powder, and packaged to obtain the wettable albendazole ivermectin powder of the present invention.
Embodiment 2
[0027] Example 2 Preparation of wettable albendazole and ivermectin powder of the present invention
[0028] Take 8g albendazole, 0.4g ivermectin, 2g magnesium stearate, 57g powdered sugar, 7g sodium lauryl sulfate, 4g xanthan gum, 0.8g fresh milk flavor, 0.8g sodium saccharin, and citric acid Sodium 20g, the above-mentioned raw and auxiliary materials are mixed uniformly, crushed to 200 mesh ultra-fine powder, and packaged to obtain the wettable albendazole ivermectin powder of the present invention.
Embodiment 3
[0029] Example 3 Preparation of wettable albendazole and ivermectin powder of the present invention
[0030] Take 6g albendazole, 0.8g ivermectin, 1.5g magnesium stearate, 64.3g powdered sugar, 5g sodium lauryl sulfate, 6g xanthan gum, 0.7g fresh milk flavor, 0.7g sodium saccharin, 15g of sodium citrate, the above-mentioned raw and auxiliary materials are mixed uniformly, crushed to 200 mesh ultra-fine powder, and packaged to obtain the wettable albendazole ivermectin powder of the present invention.
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Abstract
The invention provides wettable albendazole ivermectin powder which is prepared from the following raw materials and auxiliary materials in parts by weight: 5-20 parts of albendazole, 0.1-1.6 parts of ivermectin, 0.5-3 parts of magnesium stearate, 33.9-70.7 parts of powdered sugar, 3-11 parts of sodium dodecyl sulfate, 0-8 parts of xanthan gum, 0.6-1 part of fresh milk essence, 0.6-1 part of saccharin sodium and 10-30 parts of sodium citrate. The invention also provides a preparation method and application of the wettable albendazole ivermectin powder. The wettable albendazole ivermectin powder significantly improves the dispersity of the ivermectin and albendazole in water to ensure that the ivermectin and the albendazole can be uniformly distributed in the water for a long time to facilitate clinical water drinking and administration; and the palatability of the albendazole ivermectin powder is greatly improved, and when used on faunas with sensitive tastes, such as pigs and the like, the albendazole ivermectin powder has a food calling function. The wettable albendazole ivermectin powder is simple in preparation process, low in production cost and suitable for industrial large-scale production.
Description
Technical field [0001] The invention relates to a wettable albendazole ivermectin powder and a preparation method and application thereof. Background technique [0002] Since the 1940s, the research and development of anthelmintics has been extremely hot, during which gratifying results have been achieved; especially the discovery of avermectins in 1976, which opened a new era in the research of anthelmintics. . This type of compound has a strong repellent effect on nematodes and arthropods that parasitize animals, so that the dosage of antihelminthic drugs is reduced from mg / kg to μg / kg. At present, the commercialized drugs in this category include Avermectin (Avermectin, AVM), Ivermectin (IVM), Doramectin (DRM), Eprinomectin (Eprinomectin, EPM, also known as Ipramectin, Epremectin), Selamectin (SLM) and Moxidectin (Moxidectin or Milbemycin, MXD, also known as Moxidinol, Moxiectin), etc. Due to its excellent anthelmintic activity and high safety, avermectins are regarded as t...
Claims
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