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Application of tetrahydrocorysamine in preparation of medicine for treating senile dementia

A Tetrahydrocorydalis amine, senile technology, applied in the direction of drug combination, pharmaceutical formula, organic active ingredients, etc., to improve the body's antioxidant capacity, improve cognitive impairment, and reduce free radical oxidative damage

Active Publication Date: 2013-10-23
BEIJING YILING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Corydalis total alkaloids are the total alkaloids extracted from Corydalis, the total alkaloids of Corydalis can resist the aging of mice induced by D-galactose [Bai Xue, Yang Jie, et al. The influence of related indicators in model mice, Guizhou Medicine, 2008, 32 (5): 399-401], suggesting that Corydalis may have anti-senile dementia effect, but Corydalis contains many kinds of alkaloids, no It is reported in the literature that Corydalis amine has anti-senile dementia effect

Method used

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  • Application of tetrahydrocorysamine in preparation of medicine for treating senile dementia
  • Application of tetrahydrocorysamine in preparation of medicine for treating senile dementia
  • Application of tetrahydrocorysamine in preparation of medicine for treating senile dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0137] Embodiment 1: Preparation of Corydalis samine tablet

[0138] Weigh 0.1g of Corydalis thamine raw material, add 30g of microcrystalline cellulose, 170g of lactose, mix well, add 30mL of 5% povidone K30 aqueous solution, add 10mL of water, stir well, mix well, and use a 24-mesh sieve Granulate, dry at 70°C, granulate, add 1% magnesium stearate, mix well, compress into tablets, and make 1000 tablets.

Embodiment 2

[0139] Embodiment 2: Preparation of Corydalis samine capsules

[0140] Weigh 0.1g of Corydalis thamine raw material, add 20g of microcrystalline cellulose, add 10g of crospovidone, 220g of lactose, mix well, add 30mL of 5% povidone K30 aqueous solution, add 15mL of water, and stir well , mixed evenly, granulated with a 24-mesh sieve, dried at 70°C, granulated, added with 1% magnesium stearate, mixed evenly, and packed into capsules to obtain 1000 capsules.

Embodiment 3

[0141] Embodiment 3: Corydalis samine drop pill preparation

[0142] Weigh 100g of polyethanol 6000, melt it in a water bath at 70°C, add 0.1g of Corydalis samine raw material, stir while adding, stir well after adding, drop into pellets, and make 3000 dropping pills.

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Abstract

The invention discloses an application of tetrahydrocorysamine in preparation of a medicine for treating senile dementia. The tetrahydrocorysamine is an alkaloid separated from a traditional Chinese medicine of rhizoma corydalis, the rhizoma corydalis has the efficacies of invigorating the circulation of blood, regulating the flow of vital energy, and relieving pain, and is mainly applied to treating chest and hypochondrium, stomach duct and abdomen pain, amenorrhea, dysmenorrhea, postpartum blood stasis, fall swelling and pain.

Description

technical field [0001] The present invention relates to a new application of Corydalis samine, in particular to the application of Corydalis samine in the preparation of medicaments for treating senile dementia. Background technique [0002] Alzheimer's Disease (AD), also known as senile dementia, is an senile disease caused by chronic neurodegenerative or cerebrovascular damage, which causes brain parenchyma damage, brain dysfunction or loss. Nerve cell damage is closely related to the occurrence and development of cerebrovascular diseases [Yuan Zhengzhong, Zhu Lingqun. Effects of geniposide, baicalin and berberine on the expression of adhesion molecules in mouse brain microvascular endothelial cells during hypoxia / reoxygenation injury[ D]. Beijing University of Traditional Chinese Medicine Master's Degree Thesis, 2005.]. The main clinical manifestations are memory loss, persistent cognitive decline, and movement disorders, accompanied by a series of psychiatric symptoms. ...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61P25/28
Inventor 梁俊青吕子明田书彦王宏涛姚兵吴士珍张梓倩徐明远周丽涛赵韶华李向军马桂云
Owner BEIJING YILING PHARMA
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