Application of n-3 unsaturated fatty acid in preparation of medicine for preventing and treating traumatic brain injury

An unsaturated fatty acid, traumatic technology, applied in the field of medicine, can solve the problems of lack of treatment methods and preventive measures, and achieve the effects of improving learning and memory functions, facilitating recovery, and inhibiting white matter damage

Inactive Publication Date: 2013-10-30
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the past few decades of relevant research in this field, although the mechanism of traumatic brain injury has been deeply understood, there is still a lack of effective treatment and preventive measures so far.

Method used

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  • Application of n-3 unsaturated fatty acid in preparation of medicine for preventing and treating traumatic brain injury
  • Application of n-3 unsaturated fatty acid in preparation of medicine for preventing and treating traumatic brain injury
  • Application of n-3 unsaturated fatty acid in preparation of medicine for preventing and treating traumatic brain injury

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Experimental program
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Effect test

Embodiment 1

[0049] Embodiment 1 Animal experiment

[0050] 1. Experimental materials and methods

[0051] 1.1 Experimental animals and grouping

[0052] Clean grade juvenile male C57 / BL6 mice (provided by the Animal Center of the Chinese Academy of Sciences), 3 weeks old, 10-12g, the animals were divided into two groups before operation, one group was given a normal diet (excluding n-3PUFAs), that is, the RD group; One group was given a fish oil diet, that is, the FOD group, each 24g of food contained 1360mg of fish oil, and both groups were fed and intervened in the animal room of this laboratory for 60 days, at a room temperature of 20-22°C, with 12 hours of light and 12 hours of darkness every day, so that the animals could adapt to the environment . During the experiment, the mice were randomly divided into RD-sham group, FOD-sham group, RD-CCI group, and FOD-CCI group, and 40 mice in each group were evaluated for neurological function (12 mice) and water maze test (8 mice). Histol...

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Abstract

The invention belongs to the field of medical technology, and relates to an application of n-3 unsaturated fatty acid in preparation of a medicine for preventing and treating traumatic brain injury. The experimental results about the function of n-3PUFAs (polyunsaturated fatty acids) in resisting traumatic brain injury show that the n-3 unsaturated fatty acid can remarkably improve sense and motor functions of a mice after traumatic brain injury, slightly reduces the deletion of brain tissue after injury, inhibits the inflammatory response from excessive activation, promotes the repair of white matter damage, obviously reduces the degeneration and necrosis of nerve cells of CA3 area of hippocampus, and improves the study and memory functions. The n-3PUFAs has a definite neuroprotective effect in resisting brain injury, can be used for preparing nerve protective medicines, and can be used for preventing and treating acute or chronic injury caused by the traumatic brain injury.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to the new medicinal use of n-3 unsaturated fatty acids (n-3PUFAs), in particular to the use of n-3 unsaturated fatty acids in the preparation of drugs for the prevention and treatment of traumatic brain injury; The n-3 unsaturated fatty acid of the invention can be used to prepare medicines with neuroprotective effect and anti-traumatic brain injury. Background technique [0002] Traumatic brain injury (traumaitc brain injury, TBI) is one of the common emergencies in the field of neurosurgery. According to reports, it has become the first cause of death and disability in young adults under the age of 45 in the world. Medical practice shows that traumatic brain injury patients need to invest a lot of medical resources and health care costs while suffering major trauma, and have a series of social and family problems. According to statistics, in the United States alone, there are mor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/201A61K31/202A61P25/00
Inventor 高艳琴濮宏建陈俊张雯婷张佳
Owner FUDAN UNIV
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