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A tumor photothermal resection device based on x-ray heating technology

An X-ray and heating technology, applied in the field of medical testing, can solve the problem of reduced excitation light energy and achieve the effect of preventing the temperature from being too high

Inactive Publication Date: 2017-01-11
DALIAN MARITIME UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, as far as the current PTA research is concerned, even if the infrared light with the maximum wavelength is used for excitation, its effective range of action in biological tissues is still limited to the biological epidermis, and with the increase of the transmission depth, the energy of the excitation light decreases. drop rapidly
Therefore, current PTA technology still has significant limitations

Method used

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  • A tumor photothermal resection device based on x-ray heating technology
  • A tumor photothermal resection device based on x-ray heating technology
  • A tumor photothermal resection device based on x-ray heating technology

Examples

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Embodiment 1

[0034] A tumor photothermal ablation device based on X-ray heating technology, comprising an X-ray heat radiator 2, a spectral temperature sensor 3, a radiation intensity controller 4, and an X-ray source 1, and the spectral temperature sensor 3 includes a fluorescent receiver 311, optical fiber 32, spectrometer 331, signal processing and display system 341, the fluorescence receiver 311 is connected to one end of the spectrometer 331 through the optical fiber 32, the other end of the spectrometer 331 is connected to the signal processing and display system 341, the X-ray source 1 The X-ray source 1 , the radiation intensity controller 4 and the spectral temperature sensor 3 are located outside the living body through the connection of the radiation intensity controller 4 with the signal processing and display system 341 . The X-ray heat radiator 2 includes X-ray heating particles 21, a temperature-sensitive X-ray luminescent particle shell 22, an amino-modified silica shell 23...

Embodiment 2

[0043] The difference with embodiment 1 is:

[0044] The preparation method of the X-ray heat radiator is as follows:

[0045] ① Preparation of X-ray pyrogenic particles:

[0046] 150mmol NaEt 2 CNS 2 ·3H 2 O was dissolved in 1000ml ethanol to obtain solution I, and 50mmol GdCl 3 Dissolve in 250ml ethanol to obtain solution II, mix solution I and solution II, stir for 30 minutes, filter to obtain a white solid, wash with ethanol and distilled water for 5 times, recrystallize with chloroform, and dry at 60°C for 12 hours to obtain Gd(S 2 CNEt 2 ) 3 ; 10mmol Gd(S 2 CNEt 2 ) 3 Add 320ml of acetonitrile into a 400ml polytetrafluoroethylene autoclave, keep the temperature at 200°C for 12h, cool naturally to room temperature, filter to obtain an orange solid, wash with ethanol for 5 times, and dry at 8°C under a vacuum of 10Pa for 10h to obtain a particle size of 40nm Gd 2 S 3 Nano X-ray pyrogenic particles.

[0047] ②Preparation of temperature-sensitive X-ray luminesce...

Embodiment 3

[0052] A tumor photothermal resection device based on X-ray heating technology, comprising an X-ray thermal radiator 2, a spectral temperature sensor 3, a radiation intensity controller 4, and an X-ray source 1, and the spectral temperature sensor 3 includes a collimator Lens I 312, optical fiber 32, collimating lens II 332, program-controlled three-dimensional grating group 342, photodetector array 352, computer 362, the collimating lens I 312 is connected to one side of the collimating lens II 332 through the optical fiber 32, and the collimating lens II 332 The other side is connected with one end of the photodetector array 352 through the program-controlled three-dimensional grating group 342, and the other end of the photodetector array 352 is connected with the computer 362, and the X-ray source 1 is connected with the computer 362 through the radiation intensity controller 4, and the X-ray The ray source 1, the ray intensity controller 4, and the spectral temperature sen...

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Abstract

The invention relates to a tumor photo-thermal excision device based on the X-ray heating technology and belongs to the technical field of medical detection. The tumor photo-thermal excision device comprises an X-ray thermal radiator. The X-ray thermal radiator comprises an X-ray heating particle, a temperature-sensitive X-ray luminous particle and an amino-modified silicon dioxide shell layer. The amino-modified silicon dioxide shell layer covers the temperature-sensitive X-ray luminous particle and the X-ray heating particle. Or, the amino-modified silicon dioxide shell layer covers the temperature-sensitive X-ray luminous particle and the temperature-sensitive X-ray luminous particle covers the X-ray heating particle. The tumor photo-thermal excision device based on the X-ray heating technology has the advantage of killing tumor cells without damaging ordinary cells.

Description

technical field [0001] The invention relates to a tumor photothermal resection device based on X-ray heating technology, which belongs to the technical field of medical detection. Background technique [0002] With the increasing pressure of people's life, malignant tumor has become the number one killer that seriously threatens the life and health of people in our country and even in the world. Radiation therapy, which uses exposure to high-energy radiation (such as X-rays, etc.) to destroy malignant cells, has been the most widely used and effective treatment since it was first reported in 1896. To prevent tumor recurrence, radiotherapy usually requires a certain course of treatment to increase the total radiation dose. However, while high-dose radiation kills tumor cells, the normal tissues around the tumor will also inevitably be damaged, resulting in various side effects and even pathological changes. For this reason, people are eagerly looking forward to the developm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16
Inventor 付姚段晓龙邢明铭张楠罗昔贤
Owner DALIAN MARITIME UNIVERSITY
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