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Novel target spot for treatment of pulmonary arterial hypertension

A technology for pulmonary arterial hypertension and new targets, applied in animal/human proteins, receptors/cell surface antigens/cell surface determinants, specific peptides, etc., can solve problems such as unclear mechanism of action and regulation

Inactive Publication Date: 2013-12-25
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the mechanism and regulation of 5-HT2BR in PAH are still unclear

Method used

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  • Novel target spot for treatment of pulmonary arterial hypertension
  • Novel target spot for treatment of pulmonary arterial hypertension

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Experimental program
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Effect test

Embodiment Construction

[0014] figure 1 Increased expression of 5-HT2BR in rats with pulmonary arterial hypertension

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Abstract

The invention discloses a novel target spot for the treatment of pulmonary arterial hypertension. The novel target spot for the treatment of pulmonary arterial hypertension aims at a serotonin 2B receptor (5-HT2BR); pulmonary arterial hypertension has a significant characteristic of high shrinkage in pulmonary artery; and inhibition on activity of the 5-HT2BR can significantly inhibit the systolic function of the pulmonary artery. The receptor can be used as a novel target spot for the treatment of pulmonary hypertension therapy.

Description

technical field [0001] The invention relates to five serotonin type 2B receptors (5-HT2BR) which play an important role in the process of pulmonary arterial hypertension by participating in the contraction of pulmonary arteries, thereby serving as a new target for treating pulmonary arterial hypertension. Background technique [0002] Pulmonary arterial hypertension (PAH) is a chronic disease characterized by pulmonary artery hyperconstriction and vascular remodeling accompanied by increased pulmonary artery pressure and right ventricular failure [1]. PAH has become a common disease that seriously threatens human physical and mental health. . In normal people, the pulmonary artery pressure is 12-16mmHg at rest, and when the pulmonary artery pressure is higher than 25mmHg, it is defined as pulmonary hypertension. The main symptoms of PAH include shortness of breath, dizziness and fainting, chest pain, etc. PAH is divided into primary and secondary. Secondary pulmonary hype...

Claims

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Application Information

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IPC IPC(8): C07K14/705
Inventor 汪南平刘雅涵赵蓓蕾
Owner PEKING UNIV
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