Method for inducing in vivo migration of stem cell

Abstract

The present invention relates to an implantable composition for treating a damaged tissue and a method for inducing an in vivo migration of a cell for treatment to a damaged tissue region. The present invention treats the damaged tissue by inducing / promoting homing of a cell for tissue generation by implanting a biodegradable scaffold reacted with chemotactic factors (for example, IL-8 or MIP-3±) to a damaged location (for example, joint cartilage or skin). Thus, the composition of the present invention can not only be applied to the treatment of a damaged bone tissue, a joint cartilage, or a skin tissue more conveniently and efficiently compared to the conventional technology, but can also be used as a useful treatment supplement agent in cell treatment using allogeneic cell by enabling efficient utilization of cell resources for treatment, the cell resources which are high in scarcity.

Description

【Technical field】 [0001] The present invention relates to a transplant composition for treating damaged tissue and a method for inducing migration of therapeutic cells to the damaged tissue site in vivo. 【Background technique】 [0002] Stem cell is a kind of cell that can differentiate organisms that make up biological tissues into various cells. It is a general term for undifferentiated cells that can be obtained from various tissues of embryos, fetuses, and adults before differentiation (differentiation). Stem cells are characterized in that they are differentiated into specific cells by a differentiation stimulus (environment), and unlike differentiated cells that stop cell division, they can produce (self-renewal) cells identical to themselves through cell division, so they have the ability to proliferate (proliferation; expansion) characteristics, the above-mentioned stem cells can also differentiate into other cells through other environments or other differentiation s...

AI Technical Summary

Problems solved by technology

[0008] Current treatments for joint damage (eg, drug therapy, surgery, gene therapy, etc.) fail to restore the damaged articular cartilage to normal articular cartilage

In addition, autologous chondrocyte transplantation is being performed in order to transplant autologous or intergraft bone-cartilage tissue or to replenish a sufficient number of chondrocytes required for regeneration in consideration of the physical characteristics of the graft, which presents a comparative advantage compared with other therapies. Good therapeutic effect, but can not overcome the following disadvantages: the actual implementation is difficult due to the limitation of donor parts or donors; patients need to bear high treatment costs and need to accept more than two operations; transplanted cells The function is significantly reduced

[0009] Recently, in order to overcome this disadvantage, artificial substitutes formed by complexes coated with cells in biodegradable synthetic polymers are being actively studied for clinical application, but this method has not overcome the existing problems. question

In this way, in order to regenerate damaged articular cartilage tissue, various treatment methods such as transplantation technology of cells and biocompatible materials have been developed, but the clinical application of composite derivatives of cells and biocompatible materials is limited and still insufficient place

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