Rapidly-dispersed water-mixed suspension medicine used for eyes

A technology of suspension and eye water, applied in the field of ophthalmic drugs, can solve the problems of drug concentration inconsistent with the nominal value, poor redispersibility, etc., and achieve the effect of good adaptability and good redispersibility
CN103565738AInactive Publication Date: 2014-02-12TIANJIN JINYAO GRP
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN JINYAO GRP
Publication Date
2014-02-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a rapidly-dispersed water-mixed suspension medicine used for eyes. The water-mixed suspension medicine comprises one or more water insoluble medicines, water, and one or more auxiliary materials suitable for water-mixed suspension used for eyes. The water-mixed suspension medicine is characterized in that particle size distribution of micro powder of the water insoluble medicines simultaneously satisfies following conditions: the D50 is 3.1-3.7 [mu]m, the maximum diameter is less than 30 [mu]m, the particle percentage of the micro powder having a diameter less than 1 [mu]m is 5%-9%, the particle percentage of the micro powder having a diameter of 1-10 [mu]m is 86%-91%, and the particle percentage of the micro powder having a diameter not more than 10 [mu]m is 93%-98%.
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Description

Technical field:

[0001] The invention relates to an ophthalmic drug, which is an aqueous suspension drug prepared from insoluble drug micropowder. Background technique:

[0002] Aqueous suspension is an important form of preparing ophthalmic preparations from water-insoluble drugs. Suspensions are thermodynamically unstable systems, and particles tend to aggregate to minimize their surface free energy. Due to the large specific surface area of ​​the particles, the chances of the particles colliding with each other increase. At the same time, there is a strong mutual attraction between the particles and a strong intermolecular force. The particles are prone to irreversible aggregation to reduce their surface energy (Wong J, Brugger A , Khare A, et al.Suspensions for intravenous (IV) injection: a review of development, preclinical and clinical aspects [J]. Adv Drug Deliv Rev, 2008, 60(8): 939-954; Kesisoglou F, Panmai S, Wu Y.Nanosizing--oral formulation development and bioph...

Claims

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