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Composition for preventing or treating bone and joint disease and preparation method and application

A joint disease and composition technology, which is applied to the composition and preparation and application fields for preventing or treating bone and joint diseases, can solve problems such as differences in safety, no difference in curative effect, etc., to increase bone density, prevent or Treating osteoporosis and osteoarthritis, enhancing the effect of cartilage tissue repair

Inactive Publication Date: 2014-02-19
北京赛而生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] The marketed glucosamine includes glucosamine sulfate and glucosamine hydrochloride. From the perspective of molecular structure, one is hydrochloride and the other is sulfate. Clinically, there is no obvious difference in curative effect between the two, but the safety of long-term use is only analyzed. there will be a difference

Method used

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  • Composition for preventing or treating bone and joint disease and preparation method and application
  • Composition for preventing or treating bone and joint disease and preparation method and application
  • Composition for preventing or treating bone and joint disease and preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Weigh 1750g of raw materials D-glucosamine hydrochloride, 1950g of calcium carbonate, 300g of soy isoflavones, 120g of microcrystalline cellulose, 80g of magnesium stearate, and 160g of PVP. Mixing, testing, filling capsules with 0.436g per capsule (0.4g in total of D-glucosamine hydrochloride, calcium carbonate and soybean isoflavones), polishing, packaging and testing.

Embodiment 2

[0050] Weigh 1750g of D-glucosamine sulfate, 1950g of calcium carbonate, 300g of soybean isoflavones, 140g of microcrystalline cellulose, 60g of magnesium stearate, and 200g of PVP. Mixing, testing, filling capsules with 0.436g per capsule (0.4g in total of D-glucosamine sulfate, calcium carbonate and soybean isoflavones), polishing, packing and testing.

Embodiment 3

[0052] Weigh raw materials D-glucosamine hydrochloride 3500g, calcium carbonate 3900g, soybean isoflavones 600g, microcrystalline cellulose 120g, magnesium stearate 40g, PVP240g. Mixing, testing, filling capsules with 0.840 g per capsule (0.8 g in total of D-glucosamine hydrochloride, calcium carbonate and soybean isoflavones), polishing, packing and testing.

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PUM

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Abstract

The invention provides a composition for preventing or treating bone and joint diseases. The composition comprises D-glucosamine or salt of D-glucosamine, a calcium compound and soy isoflavone, wherein the weight ratio of the D-glucosamine or salt of the D-glucosamine to the calcium compound to the soy isoflavone is (2.5-5.0):(1.6-4):(0.2-1.0). The invention further provides a preparation method of the composition. Pharmacological study results show that the composition has a remarkable calcium supplement effect and an estrogen-like effect, and can effectively suppress osteoclast function so as to treat osteoporosis, and meanwhile the composition provided by the invention further has the capability to stimulate chondrocyte to generate and prompt repairing capability of chondrocyte, and bone and joint diseases can be effectively prevented and treated.

Description

[0001] The present invention is a divisional application of application number 200910092158.5; [0002] The filing date of the original application is: 2009.09.02; [0003] The title of the invention of the original application is: a composition for preventing or treating bone and joint diseases and its preparation method technical field [0004] The invention relates to a composition for preventing or treating bone and joint diseases and a preparation method thereof, in particular to a health care composition for preventing osteoporosis and osteoarthropathy, a preparation method thereof and a preparation method for A pharmaceutical composition for treating osteoporosis and osteoarthropathy and a preparation method thereof. Background technique [0005] Bone and joint diseases include osteoporosis and osteoarthropathy. [0006] Osteoporosis is a systemic skeletal disease characterized by decreased bone mass and degeneration of bone microstructure, resulting in increased bo...

Claims

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Application Information

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IPC IPC(8): A61K33/10A61K31/7008A61P19/02A61P19/10A61P3/14A61K31/352
Inventor 马骉孙爽孔双泉
Owner 北京赛而生物药业有限公司
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