Asarum heterotropoide extract, preparation method and application of extract

A technology of extract and asarum, applied in the field of its preparation, extract of Asarum liaoensis, can solve the problems of less distribution of Panax notoginseng, high price, long growth cycle and the like

Inactive Publication Date: 2014-03-05
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Take the drug toothpaste with anti-inflammatory and analgesic effects as an example. The existing toothpastes such as Yunnan Baiyao toothpaste and Tianqi tooth...

Method used

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  • Asarum heterotropoide extract, preparation method and application of extract
  • Asarum heterotropoide extract, preparation method and application of extract
  • Asarum heterotropoide extract, preparation method and application of extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1 Liaoshixin extract preparation

[0043] (1) Take 200g of Asarum root or rhizome, crush it into fine powder (particle size about 1.5mm), put it into the extraction kettle, the range of extraction conditions: extraction pressure, 23MPa; extraction temperature, 35°C; sub-I pressure, 4.5MPa ; Point I temperature, 30°C; Point II pressure, 3.5MPa Point II temperature, 20°C; Extraction time, 3h; Gas flow: 20L / h. Collect the separated volatile oil from the sub-I discharge port every 0.5h (the oil yield rate is 2%).

[0044] (2) Using the saturated aqueous solution method that is easy to industrialize, take 5ml of volatile oil and add absolute ethanol to make a 50% solution; take another appropriate amount of β-CD, add 10 times the amount of water, heat to dissolve, let cool to the specified temperature, and place in On a constant temperature magnetic stirrer, keep the set temperature, start stirring, drop in the prepared ethanol solution of volatile oil, stir unti...

Embodiment 2

[0047] The quality control research of embodiment 2 Liaoshixin extract

[0048] (1) Qualitative study on the chemical constituents of Liaoshixin volatile oil (GC-MS)

[0049] Taking the LiaoXin extract obtained in Example 1, the chemical components of the LiaoXin volatile oil were qualitatively studied by using the GC-MS method, a total of 14 compounds were identified, and the relative percentages were calculated.

[0050] Instruments and materials: Agilent6890-5975 gas chromatography-mass spectrometry (Palo Alto, CA, USA), Agilent7683B series autosampler, Agilent MSD-ChemStation workstation; n-hexane (chromatographic grade, Yuwang, Shandong); anhydrous Sodium sulfate (analytical grade, Damao, Tianjin)

[0051] Preparation of sample solution: Accurately measure 1 mL of Liao Asarum volatile oil (dehydrated with anhydrous sodium sulfate), put it in a 50 mL volumetric flask, add n-hexane to make up to the mark. Store at 4°C for later use. Injection volume: 1 μL.

[0052] Resu...

Embodiment 3

[0061] Example 3 Liao Asarum Extract Preparation

[0062] (1) Take Liaoshixin root or rhizome 200g, crush it into fine powder (particle size about 1.5mm), put it into the extraction kettle, the range of extraction conditions: extraction pressure 35MPa; extraction temperature 55°C; minute I pressure, 9.5MPa; I temperature, 65°C; min II pressure, 5.5MPa min II temperature, 50°C; extraction time, 3h; gas flow: 20L / h. Every 0.5h collects the separated volatile oil (oil yield 2.5%) from the sub-I discharge port.

[0063] (2) Using the saturated aqueous solution method that is easy to industrialize, take 5ml of volatile oil and add absolute ethanol to make a 50% solution; take another appropriate amount of β-CD, add 10 times the amount of water, heat to dissolve, let cool to the specified temperature, and place in On a constant temperature magnetic stirrer, keep the set temperature, start stirring, drop in the prepared ethanol solution of volatile oil, stir until the specified time...

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Abstract

The invention relates to an asarum heterotropoide extract of asarum as well as a preparation method and application of the extract, and particularly relates to an asarum heterotropoides extract of asarum. The extract comprises essential oil and a water extract, wherein the essential oil accounts for 2% by weight, and the water extract accounts for 98% by weight. The preparation method of the extract comprises the following steps: extracting essential oil in asarum heterotropoides roots and rhizomes by adopting a supercritical fluid extraction method; including the essential oil by cyclodextrin, and hermetically storing for later use; condensing, refluxing and extracting dregs by water; filtering by an aqueous extract, and drying to obtain powder; finally evenly mixing a beta-cyclodextrin inclusion compound with dry powder, so as to obtain the asarum heterotropoides extract, and hermetically storing. Application of the asarum heterotropoides extract in preparation of two oral appliances relates to a drug paste and an oral patch. The drug paste disclosed by the invention has the effects of preventing and treating odontalgia, gingivitis, periodontitis and dental ulcer. The oral patch has the efficacies of treating the dental ulcer, easing pain, diminishing inflammation and preventing gum bleeding.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to Liaoasarum extract, its preparation method and application. Background technique [0002] With the increasing awareness of people's health care and the rapid development of science and technology, more demands have been put forward for oral health care, such as auxiliary prevention or treatment of oral and dental diseases. Therefore, components with specific functions are often added to oral products to make them have specific functions, such as whitening, anti-cavity toothpaste, hypoallergenic toothpaste, especially mouthwash for oral ulcers, periodontitis and gingivitis. , oral sprays and other oral products. Among them, the addition of Chinese herbal medicine plants in oral products has won the favor of consumers because of its natural efficacy additives, remarkable effects and high safety. Take the drug toothpaste with anti-inflammatory and a...

Claims

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Application Information

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IPC IPC(8): A61K36/264A61K8/97A61K9/70A61P31/04A61P29/00A61P1/02A61Q11/00
Inventor 袁丹肖锋王冰冰张国哲
Owner SHENYANG PHARMA UNIVERSITY
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