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A kind of preparation method and application of fungus Shujin pill

A technology of fungus Shujin pills and fungus, which is applied to medical preparations containing active ingredients, pill delivery, pharmaceutical formulas, etc. It can solve the problems of large dosage for patients, rough process, and impact on application, and achieve the effect of reducing dosage

Active Publication Date: 2015-12-02
山东笑康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Fungus Shujin Pills. However, the method of powdering is rough, backward, and has many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects this product. products in clinical application

Method used

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  • A kind of preparation method and application of fungus Shujin pill

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Take 200g of fungus, 100g of angelica, 50g of Chuanxiong, 100g of medlar, 100g of fried herb, 50g of fried Eucommia ulmoides, 50g of Achyranthes bidentata, and 100g of Baijushengzi into the CO2 supercritical extractor. Ethanol is used as an entrainer, which accounts for the total extraction solvent. The volume percentage is 4%, the extraction pressure is 15MPa, the temperature is 30°C, the CO2 flow rate is 1m1 / g crude drug min, and the extraction time is 150min to obtain a supercritical extract, which is crushed into a fine powder, sieved, mixed, and refined for every 100g of powder Honey 100g, made into large honeyed pills, each weighing 4.5g.

[0017] Baijushengzi is the dry and mature fruit of Dipsacusfullonum L., a plant of Dipsacaceae, the same below.

Embodiment 2

[0019] Take 200g of fungus, 100g of angelica, 50g of Chuanxiong, 100g of medlar, 100g of fried herb, 50g of fried Eucommia with salt, 50g of Achyranthes bidentata, and 100g of Baijushengzi into CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained, which is crushed into fine powder, sieved, mixed evenly, and 100g of refined honey is added to each 100g of powder to make a large honeyed pill, that is, the weight of each pill is 4.5 g.

Embodiment 3

[0021] Take 200g of fungus, 100g of angelica, 50g of Chuanxiong, 100g of medlar, 100g of fried herb, 50g of fried Eucommia with salt, 50g of Achyranthes bidentata, and 100g of Baijushengzi into CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained, which is crushed into fine powder, sieved, mixed, and 100g of refined honey is added to each 100g of powder to make a large honeyed pill, that is, the weight of each pill is 4.5 g.

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Abstract

The invention provides a preparation method of an agaric sinew-relaxing pill. The pill is prepared from the following raw medicines: 200 g agaric, 100 g angelica sinensis, 50 g rhizoma chuanxiong, 100 g wolfberry fruit, 100 g fried atractylodes, 50 g salt fried eucommia bark, 50 g achyranthes bidentata and 100 g sesamum indicum. The pill is prepared by adopting supercritical extraction equipment, so that the content is greatly increased and the dose is reduced. The invention further provides application of the agaric sinew-relaxing pill used for preparing a medicine for inhibiting the proliferation of a human leukemia cell: K562 cell.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of fungus Shujin pills. Background technique [0002] Fungus Shujin Wan is recorded in the standard WS3-B-0202-90 of the Ministry of Health, 200g of fungus, 100g of angelica, 50g of Chuanxiong, 100g of medlar, 100g of fried herb, 50g of fried Eucommia with salt, 50g of Achyranthes bidentata, 100g of Baijushengzi, and the above eight flavors , crushed into fine powder, sieved, mixed, every 100g of powder is added with 120g of refined honey to make a large honeyed pill, which can relax tendons and activate blood circulation, dispel rheumatism, and nourish liver and kidney. For soreness and weakness of the waist and knees, numbness of the limbs, convulsions. [0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Fungus Shujin Pills. However, the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/815A61K9/20A61P29/00A61P35/02
Inventor 李强
Owner 山东笑康生物科技有限公司