Device for simulating digestion in oral cavities and method for applying device

A technology of oral cavity and reactor, applied in the direction of educational appliances, teaching models, instruments, etc.

Active Publication Date: 2014-03-26
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, so far, no one has patented a detailed description of oral digestion specifically.

Method used

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  • Device for simulating digestion in oral cavities and method for applying device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Oral simulated digestion of cornstarch.

[0015] (1) Saliva collection and enzyme activity determination.

[0016] Saliva collection.

[0017] Fresh clarified saliva samples were collected from a healthy volunteer. The volunteer had no chronic diseases and had not used antibiotics for at least 3 months. Before saliva collection, the volunteer was restricted from eating and drinking.

[0018] Collection is by direct spitting. The specific collection method steps are as follows.

[0019] (a) Volunteers drank a few sips of water and rinsed their mouth for at least 40 seconds to achieve a "neutral" oral environment.

[0020] (b) During the first 40 seconds or so, saliva is spit out at a certain frequency and discarded. Then, for the next 2.5 minutes, volunteers were given a graduated test tube to collect saliva from. The best way to spit is to sit down and tilt your head slightly so that the saliva collects in your mouth. Then slowly spit every 40 seconds.

[0021]...

Embodiment 2

[0041] Oral simulated digestion of plant polysaccharides.

[0042] (1) Saliva collection and enzyme activity determination.

[0043] Saliva collection.

[0044] Fresh clarified saliva samples were collected from a healthy volunteer. The volunteer had no chronic diseases and had not used antibiotics for at least 3 months. Before saliva collection, the volunteer was restricted from eating and drinking.

[0045] Collection is by direct spitting. The specific collection method steps are as follows.

[0046] (a) Volunteers drank a few sips of water and rinsed their mouth for at least 30 seconds to achieve a "neutral" oral environment.

[0047] (b) During the first 30 seconds or so, saliva is spit out at a certain frequency and discarded. Then, for the next 2 minutes, volunteers were given a graduated test tube to collect saliva. The best way to spit is to sit down and tilt your head slightly so that the saliva collects in your mouth. Then slowly spit every 30 seconds.

[0...

Embodiment 3

[0066] Oral simulated digestion of soy protein.

[0067] (1) Saliva collection and enzyme activity determination.

[0068] Saliva collection.

[0069] Fresh clarified saliva samples were collected from a healthy volunteer. The volunteer had no chronic diseases and had not used antibiotics for at least 3 months. Before saliva collection, the volunteer was restricted from eating and drinking.

[0070] Collection is by direct spitting. The specific collection method steps are as follows.

[0071] (a) Volunteers drank a few sips of water and rinsed their mouth for at least 30 seconds to achieve a "neutral" oral environment.

[0072] (b) During the first 30 seconds or so, saliva is spit out at a certain frequency and discarded. Then, for the next 2 minutes, volunteers were given a graduated test tube to collect saliva. The best way to spit is to sit down and tilt your head slightly so that the saliva collects in your mouth. Then slowly spit every 30 seconds.

[0073] (c) R...

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Abstract

The invention discloses a device for simulating digestion in oral cavities and a method for applying the device. The device comprises components including a saliva dish, a constant-flow pump, a water bath kettle, a grinder, a stirrer, a reactor, an electric controller and the like. The method includes regulating the temperature of the water bath kettle until the temperature of the water bath kettle reaches 37 DEG C, adding saliva into the saliva dish, adding solution or dispersion liquid of to-be-tested substances into the reactor, starting the constant-flow pump and adding the saliva into the reactor; enabling the grinder and the stirrer to simulate chewing actions of teeth and stirring actions of tongues; continuously adding the saliva into the reactor via a hose to simulate a secretion effect of salivary glands; replacing water in the water bath kettle by boiling water to remove activity of salivary amylases after the secretion effect of the salivary glands is simulated for 30-40 minutes, repeatedly carrying out a digestion simulation procedure by three times, and detecting digestion conditions of the to-be-tested substances by a liquid-phase process. The device and the method have the advantages that specific digestion simulated in the oral cavities is described in detail for the first time, structures of various portions of the oral cavities and corresponding functions of the structures of the various portions of the oral cavities are simulated, accordingly, first-step digestion conditions of various active or nutrient substances can be observed after the various active or nutrient substances are fed into human bodies, and the device and the method can assist in exploring digestion conditions of the various active or nutrient substances after the various active or nutrient substances are fed into the human bodies.

Description

technical field [0001] The invention relates to a device for simulating oral digestion and a method for using it. Background technique [0002] The world's authoritative journals stated that it is very important to study the effects of food or active substances in the human body and their mechanisms of action, because the elucidation of the mechanism of action in vivo can provide a research basis for maximizing the use of food or active substances in the human body. It can exert its physiological efficacy more effectively, and at the same time, it has guiding significance for avoiding its possible adverse side effects. The actual physiological effect of a food or active substance depends largely on what is the product of its digestion by the body. For the consideration of ethics in human body research, simulating human digestion in vitro has become the technical key to the research on the mechanism of action of food or active substances in vivo. Dynamic simulation is perfo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G09B25/00
Inventor 谢明勇聂少平胡婕伦
Owner NANCHANG UNIV
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